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. 2022 Mar 31;12(3):e059988. doi: 10.1136/bmjopen-2021-059988

Table 1.

CCNA criteria for CI with risk factors, and SCI and MCI from COMPASS-ND58

Group Core diagnostic criteria Operationalised as
CI with risk factors The absence of SCI and/or MCI based on below definitions, with two or more known risk factors for dementia Not having SCI or MCI, and having at least 2 of the following risk factors:

  • Obesity

  • Hypertension

  • Diabetes

  • Cardiovascular disease

  • Physical inactivity

  • First-degree family history of dementia

  • Dyslipidaemia

  • Poor sleep

  • Poor diet
SCI59 Self-experienced persistent decline in cognitive capacity in comparison with a previously normal status and unrelated to an acute event Answer ‘yes’ to both of the following questions: ‘Do you feel like your memory or thinking is becoming worse?’ and ‘Does this concern you?’
Normal age-adjusted, sex-adjusted and education-adjusted performance on standardised cognitive tests, which are used to classify MCI or prodromal AD Global CDR scale=0, Logical Memory II above ADNI education-adjusted cutoffs (≥9 for 16+ years of education, ≥5 for 8–15 years of education and ≥3 for 0–7 years of education); ADAS-Cog word list recall score >5; MoCA total score ≥25
MCI5 Concern regarding a change in cognition Report from patient and/or informant of such
Impairment in one or more cognitive domains One or more of the following:

  • Logical Memory below ADNI cut-offs ((≥9 for 16+ years of education, ≥5 for 8–15 years of education and ≥3 for 0–7 years of education)

  • ADAS-Cog word list recall <6

  • MoCA score 13–24 inclusive

  • Global CDR >0
Preservation of independence in functional abilities Score >14/23 on the Lawton-Brody IADL Scale
Not demented Global CDR ≤0.5

AD, Alzheimer’s disease; ADAS-Cog, Alzheimer’s Disease Assessment Scale-Cognitive; ADNI, Alzheimer’s Disease Neuroimaging Initiative; CCNA, Canadian Consortium on Neurodegeneration in Aging; CDR, Clinical Dementia Rating; CI, cognitively intact; COMPASS-ND, Comprehensive Assessment of Neurodegeneration and Dementia; IADL, Instrumental Activities of Daily Living; MCI, mild cognitive impairment; MoCA, Montreal Cognitive Assessment; SCI, subjective cognitive impairment.