Figure 4.

Protein-protein interaction networks of upregulated DEGs in C. perfringens sialidase treated SFs. Upregulated DEGs identified in Figure 3 were used to perform protein-protein interaction enrichment in Metascape (https://metascape.org/ ). Genes are represented by coloured circles, size is directly proportional to the number of genes in each node. DEGs genes clustered a total of 10 independent nodes based on known protein-protein interactions. Functional pathways significantly represented in each node are shown. Nodes are classified into two main categories based on the functional roles: ‘rheumatoid arthritis’ (A) and ‘response to virus’ (B).