Table 3.

The univariate analysis of 5-year survival prognostic factors in lung adenocarcinoma patients

Variable	Univariate analysis
	P value＞│z│	HR (95% CI)
Tumour budding (10 HPF)
Low (n=141) vs high (n=193)	0.011*	1.374 (1.077 to 1.753)
Nuclear size
Small (n=145) vs large (n=189)	0.023*	1.467 (1.054 to 2.042)
Smallest tumour cell nest
Single cell (n=166) vs 2–4cells (n=168)	0.699	0.943 (0.702 to 1.267)
Gender
Male (n=208) vs female (n=172)	0.252	0.835 (0.614 to 1.136)
Age(years)
≤65 (n=150) vs＞65 (n=228)	0.050	1.362 (1.00 to 1.854)
Pleural invasion
Absent (n=151) vs present (n=229)	0.021*	1.560 (1.071 to 2.272)
Vascular invasion
Absent (n=179) vs present (n=201)	0.001*	2.357 (1.401 to 3.965)
STAS
Absent (n=102) vs present (n=278)	<0.001*	2.874 (1.690 to 4.887)
Necrosis
Absent (n=114) vs present (n=266)	0.047*	1.315 (1.004 to 1.722)
Histological subtype
Adherent type (n=63) vs acinar type (n=140) vs papillary type (n=49) vs micropapillary type (n=62) vs solid type (n=66)	0.014*	0.858 (0.759 to 0.969)
Interstitial fibrosis
Absent(n=11) vs present(n=369)	0.200	0.900 (0.766 to 1.057)
pT
pT1 +pT2(n=295) vs pT3 +pT4 (n=85)	<0.001*	2.069 (1.687 to 2.538)
pN
pN0(n=195) vs pN1 +pN2+pN3 (n=185)	<0.001*	1.974 (1.363 to 2.858)
TNM stage
Ⅰ+ Ⅱ(n=273) vs Ⅲ+ Ⅳ(n=107)	0.003*	0.484 (0.301 to 0.780)

*P＜0.05

HPF, high-power field; STAS, spread through air spaces; TNM, tumour node metastasis.