Table 4.
Entomological outcomes
|
Vector density |
Sporozoite rate |
Entomological inoculation rate |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Number of households analysed | Number of female Anopheles | Density per household per night | Adjusted density ratio (95% CI)* | p value† | Number of sporozoite-positive female Anopheles | Number of female Anopheles tested | Sporozoite rate | Adjusted odds ratio (95% CI)* | p value† | Mean per household per night | Adjusted density ratio (95% CI)*‡ | p value† | |
| Pyrethroid-only group | |||||||||||||
| Year 1 | 670 | 1658 | 2·47 | 1 (ref) | .. | 14 | 1009 | 1·4% | 1 (ref) | .. | 0·038 | 1 (ref) | .. |
| Year 2 | 838 | 6352 | 7·58 | 1 (ref) | .. | 47 | 2422 | 1·9% | 1 (ref) | .. | 0·093 | 1 (ref) | .. |
| Overall | 1508 | 8010 | 5·31 | 1 (ref) | .. | 61 | 3431 | 1·8% | 1 (ref) | .. | 0·069 | 1 (ref) | .. |
| Pyriproxyfen group | |||||||||||||
| Year 1 | 672 | 795 | 1·18 | 0·62 (0·36–1·08) | 0·0899 | 12 | 633 | 1·9% | 1·93 (0·74–5·01) | 0·1778 | 0·020 | 0·48 (0·19–1·20) | 0·1182 |
| Year 2 | 840 | 7633 | 9·09 | 0·90 (0·56–1·44) | 0·6560 | 34 | 2144 | 1·6% | 0·95 (0·52–1·73) | 0·8683 | 0·097 | 0·82 (0·40–1·67) | 0·5800 |
| Overall | 1512 | 8428 | 5·57 | 0·77 (0·52–1·14) | 0·1947 | 46 | 2777 | 1·7% | 1·15 (0·68–1·93) | 0·6098 | 0·064 | 0·73 (0·40–1·34) | 0·3108 |
| Chlorfenapyr group | |||||||||||||
| Year 1 | 671 | 435 | 0·65 | 0·33 (0·19–0·58) | 0·0001 | 2 | 340 | 0·6% | 0·63 (0·13–3·07) | 0·5625 | 0·003 | 0·08 (0·02–0·40) | 0·0020 |
| Year 2 | 840 | 5058 | 6·02 | 0·51 (0·32–0·83) | 0·0064 | 12 | 1526 | 0·8% | 0·43 (0·20–0·93) | 0·0316 | 0·015 | 0·18 (0·08–0·40) | <0·0001 |
| Overall | 1511 | 5493 | 3·64 | 0·43 (0·29–0·64) | <0·0001 | 14 | 1866 | 0·8% | 0·48 (0·24–0·95) | 0·0352 | 0·010 | 0·15 (0·07–0·31) | <0·0001 |
| Piperonyl butoxide group | |||||||||||||
| Year 1 | 672 | 500 | 0·74 | 0·42 (0·24–0·73) | 0·0023 | 6 | 447 | 1·3% | 1·04 (0·34–3·24) | 0·9418 | 0·010 | 0·27 (0·09–0·79) | 0·0167 |
| Year 2 | 840 | 3914 | 4·66 | 0·64 (0·40–1·03) | 0·0678 | 33 | 1702 | 1·9% | 0·84 (0·46–1·53) | 0·5618 | 0·059 | 0·67 (0·34–1·31) | 0·2427 |
| Overall | 1512 | 4414 | 2·92 | 0·54 (0·37–0·80) | 0·0020 | 39 | 2149 | 1·8% | 0·89 (0·52–1·53) | 0·6747 | 0·038 | 0·56 (0·32–0·98) | 0·0429 |
For time-by-study group interaction, pinteraction=0·5173 for vector density, pinteraction=0·6454 for sporozoite rate, and pinteraction=0·5900 for entomological inoculation rate.
*
Adjusted for baseline cluster-level variables used in restricted randomisation.
†
p<0·017 was considered statistically significant after Bonferroni correction.
‡
Weighted to account for the proportion of mosquitoes sampled to be tested for sporozoites.