. 2022 Mar 14;24(3):178–189. doi: 10.1089/dia.2021.0319

Table 3.

Sensor Glucose, Glucose Variability, and Insulin Delivery, During the Run-in Period and Study Phase

	Overall (n = 157)			Adolescents (n = 39)			Adults (n = 118)
	Run-in^a	Study^b	P	Run-in^a	Study^b	P	Run-in^a	Study^b	P
24-h day
SG, mg/dL	153 ± 16	148 ± 10	<0.001^d	162 ± 16	150 ± 8	<0.001	151 ± 15	147 ± 11	<0.001
CV of SG, %	35.0 ± 5.0	34.2 ± 4.1	0.003	36.5 ± 4.8	35.7 ± 4.1	0.202	34.5 ± 5.0	33.7 ± 3.9	0.008
Total insulin, units	54.9 ± 25.8	56.7 ± 28.4	0.002^d	60.0 ± 16.3	63.1 ± 17.3	0.007	53.2 ± 28.1	54.6 ± 31.0	0.103^d
Total basal insulin, units	25.1 ± 13.6	23.6 ± 13.2	<0.001^d	25.2 ± 8.7	24.4 ± 8.4	0.265	25.1 ± 14.9	23.3 ± 14.5	<0.001^d
Total bolus insulin, units	29.8 ± 14.8	33.1 ± 16.8	<0.001^d	34.8 ± 10.9	38.7 ± 10.1	0.002	28.1 ± 15.5	31.3 ± 18.2	<0.001^d
Auto Correction, units	0.0 ± 0.4	7.5 ± 6.1	<0.001^d	0.0 ± 0.2	8.3 ± 3.3	<0.001	0.0 ± 0.5	7.3 ± 6.7	<0.001^d
Auto Correction, %^c	0.2 ± 1.4	22.0 ± 9.3	<0.001^d	0.1 ± 0.5	21.6 ± 7.0	<0.001	0.2 ± 1.6	22.1 ± 10.0	<0.001^d
Daytime (6 AM–12 AM)
SG, mg/dL	155 ± 17	151 ± 12	<0.001^d	164 ± 17	154 ± 10	<0.001^d	151 ± 16	150 ± 12	0.113
CV of SG, %	35.0 ± 5.1	34.5 ± 4.0	0.157^d	36.7 ± 4.9	36.0 ± 4.1	0.261	34.5 ± 5.1	34.0 ± 3.8	0.129
Total insulin, units	46.4 ± 21.7	47.5 ± 23.6	0.024^d	51.4 ± 13.7	53.4 ± 14.2	0.061	44.7 ± 23.6	45.6 ± 25.7	0.250^d
Total basal insulin, units	18.7 ± 10.1	17.2 ± 9.8	<0.001^d	18.6 ± 6.6	17.7 ± 6.1	0.092	18.7 ± 11.0	17.0 ± 10.8	<0.001^d
Total bolus insulin, units	27.6 ± 13.8	30.3 ± 15.3	<0.001^d	32.7 ± 10.1	35.7 ± 9.3	0.017	26.0 ± 14.5	28.5 ± 16.5	<0.001^d
Auto Correction, units	0.0 ± 0.4	5.9 ± 4.8	<0.001^d	0.0 ± 0.2	6.5 ± 2.7	<0.001^d	0.0 ± 0.4	5.7 ± 5.4	<0.001^d
Auto Correction, %^c	0.2 ± 1.3	18.8 ± 8.7	<0.001^d	0.1 ± 0.5	18.5 ± 6.6	<0.001^d	0.2 ± 1.5	18.9 ± 9.2	<0.001^d
Nighttime (12 AM–6 AM)
SG, mg/dL	150 ± 19	140 ± 13	<0.001	156 ± 19	140 ± 12	<0.001	148 ± 19	140 ± 14	<0.001
CV of SG, %	33.1 ± 6.1	30.6 ± 5.2	<0.001^d	34.1 ± 5.9	32.0 ± 5.0	0.008	32.7 ± 6.1	30.1 ± 5.2	<0.001^d
Total insulin, units	8.6 ± 4.8	9.3 ± 5.5	<0.001^d	8.7 ± 3.5	9.8 ± 3.8	<0.001^d	8.5 ± 5.1	9.1 ± 5.9	<0.001^d
Total basal insulin, units	6.5 ± 3.7	6.4 ± 3.7	0.990^d	6.6 ± 2.3	6.7 ± 2.3	0.593	6.4 ± 4.0	6.4 ± 4.0	0.672^d
Total bolus insulin, units	2.1 ± 2.1	2.8 ± 2.5	<0.001^d	2.1 ± 2.1	3.1 ± 2.2	<0.001	2.1 ± 2.0	2.8 ± 2.6	<0.001^d
Auto Correction, units	0.0 ± 0.1	1.7 ± 1.5	<0.001^d	0.0 ± 0.0	1.8 ± 0.9	<0.001^d	0.0 ± 0.1	1.6 ± 1.6	<0.001^d
Auto Correction, %^c	0.5 ± 3.6	66.1 ± 22.4	<0.001^d	0.3 ± 1.3	69.9 ± 20.6	<0.001^d	0.5 ± 4.1	64.9 ± 22.9	<0.001^d

All values are shown as mean ± SD.

Run-in CGM was ∼14 days and study phase was ∼90 days.

During baseline run-in period, Auto Correction bolus was inadvertently delivered on six systems.

^{^a}

Sensor-augmented/integrated pump, PLGM, or Auto Basal use.

^{^b}

Auto Basal+Auto Correction use.

^{^c}

Factored as a percentage of total bolus insulin.

^{^d}

Wilcoxon signed-rank test.

CV, coefficient of variation; SG, sensor glucose.