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Top 10 kinase targets of AZ-23 in in vitro kinase activity screen (n = 1)
| Kinase | 0.1 μM |
0.01 μM |
|---|---|---|
| % Inhibition | ||
| TrkC | 102.8 | 97.9 |
| TrkB | 104.7 | 95.5 |
| TrkA | 101.6 | 65.7 |
| MuSK | 99.6 | 63.2 |
| Ros | 95.3 | 57.8 |
| Flt3 | 89 | 49.2 |
| PhKγ2 | 78.6 | 29.2 |
| FGFR1 | 52 | 20.3 |
| Lyn | 68.4 | 16.7 |
| ARK5 | 68.1 | 14.8 |
