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Top 10 kinase targets of compound 28 in in vitro kinase activity screen (n = 2)
| Kinase | 0.1 μM |
0.01 μM |
|---|---|---|
| % Inhibition | ||
| Flt3 | 99.3 | 97.4 |
| Ret | 95 | 75.1 |
| MuSK | 98.7 | 72.6 |
| MAP4K4 | 95.4 | 64.6 |
| Abl | 94.3 | 58.8 |
| Yes | 98 | 58.3 |
| ITK | 97.7 | 52.3 |
| Lck | 94.7 | 47.8 |
| Aurora_A | 89.7 | 42 |
| KDR | 92.3 | 38.3 |
