Table 1.
Baseline Characteristics Between Women Reporting No Anxiety/Depression Versus Anxiety/Depression on the Euro-Quality-of-Life-5 Dimension Anxiety/Depression Domain at Baseline
| Characteristic | No/slightly anxious or depressed (n = 1093) | ≥ Moderately anxious or depressed (n = 393) | Total (N = 1486) | p |
|---|---|---|---|---|
| Age (years) | 43.4 (5.5) | 42.7 (5.8) | 43.2 (5.6) | 0.02 |
| 31–39 | 255 (23.3%) | 109 (27.7%) | 364 (24.5%) | |
| 40–44 | 337 (30.8%) | 118 (30.0%) | 455 (30.6%) | |
| 45–54 | 501 (45.8%) | 166 (42.2%) | 667 (44.9%) | |
| Race | 0.02 | |||
| White | 521 (47.7%) | 178 (45.3%) | 699 (47.0%) | |
| Black | 417 (38.2%) | 177 (45.0%) | 594 (40.0%) | |
| Other | 155 (14.2%) | 38 (9.7%) | 193 (13.0%) | |
| Insurance | <0.001 | |||
| Private | 954 (87.4%) | 293 (74.9%) | 1247 (84.1%) | |
| Active military | 6 (0.5%) | 2 (0.5%) | 8 (0.5%) | |
| Other | 131 (12.0%) | 96 (24.6%) | 227 (15.3%) | |
| Medical treatment | ||||
| Currently treated for depression | 65 (6.0%) | 123 (32.1%) | 188 (12.9%) | <0.001 |
| Currently treated for anxiety | 69 (6.4%) | 145 (37.9%) | 214 (14.7%) | <0.0001 |
| Planned UF procedure | 0.83 | |||
| Myomectomy | 365 (33.4%) | 132 (33.6%) | 497 (33.4%) | |
| Hysterectomy | 516 (47.2%) | 175 (44.5%) | 691 (46.5%) | |
| Endometrial ablation | 96 (8.8%) | 37 (9.4%) | 133 (9.0%) | |
| Uterine arterial embolization | 87 (8.0%) | 37 (9.4%) | 124 (8.3%) | |
| Other | 29 (2.6%) | 12 (3.0%) | 41 (2.8%) | |
| UF symptoms at baseline | ||||
| Duration of symptoms | 5.9 (6.6) | 6.9 (7.2) | 6.1 (6.7) | 0.006 |
| Any fibroid symptoms | 1029 (94.4%) | 383 (97.5%) | 1412 (95.2%) | 0.02 |
| Bleeding symptoms | 908 (83.3%) | 352 (89.6%) | 1260 (85.0%) | 0.003 |
| Menses ≥7 days | 631 (57.9%) | 277 (70.5%) | 908 (61.2%) | <0.001 |
| Heavy menses | 840 (77.1%) | 329 (83.7%) | 1169 (78.8%) | 0.006 |
| Bleeding between periods | 509 (46.7%) | 220 (56.0%) | 729 (49.2%) | 0.002 |
| Frequent urination | 583 (53.5%) | 258 (65.6%) | 841 (56.7%) | <0.001 |
| Nocturia | 568 (52.1%) | 258 (65.6%) | 826 (55.7%) | <0.001 |
| Abdominal bloating | 762 (69.9%) | 329 (83.7%) | 1091 (73.6%) | <0.001 |
| Abdominal/pelvic pressure | 741 (68.0%) | 317 (80.7%) | 1058 (71.3%) | <0.001 |
| Pelvic pain requiring meds | 398 (36.5%) | 241 (61.3%) | 639 (43.1%) | <0.001 |
| Appear pregnant | 399 (36.6%) | 196 (49.9%) | 595 (40.1%) | <0.001 |
| Discomfort during intercourse | 412 (37.8%) | 209 (53.2%) | 621 (41.9%) | <0.001 |
| Nonmenstrual pain | 141 (12.9%) | 64 (16.3%) | 205 (13.8%) | <0.001 |
| History of anemia | 540 (50.0%) | 235 (60.4%) | 775 (52.8%) | <0.001 |
| Requiring transfusion | 85 (7.9%) | 47 (12.3%) | 132 (9.1%) | 0.010 |
| Reproductive history | ||||
| Ever pregnant | 760 (70.0%) | 278 (71.1%) | 1038 (70.3%) | 0.70 |
| Two or more pregnancies | 602 (55.1%) | 218 (55.5%) | 820 (55.2%) | 0.89 |
| Subfertility | 129 (11.8%) | 58 (14.8%) | 187 (12.6%) | 0.13 |
| Miscarriage(s) | 56 (5.1%) | 34 (8.7%) | 90 (6.1%) | 0.01 |
| Social factors | ||||
| Marital status | 0.01 | |||
| Married/living as married or with a domestic partner | 618 (57.4%) | 186 (47.9%) | 804 (54.9%) | |
| Separated | 29 (2.7%) | 15 (3.9%) | 44 (3.0%) | |
| Divorced | 106 (9.9%) | 50 (12.9%) | 156 (10.7%) | |
| Widowed | 9 (0.8%) | 7 (1.8%) | 16 (1.1%) | |
| Single, never married | 314 (29.2%) | 130 (33.5%) | 444 (30.3%) | |
| Highest education | <0.001 | |||
| Less than high school | 18 (1.7%) | 10 (2.6%) | 28 (1.9%) | |
| High school (grade 12 or general equivalency diploma) | 103 (9.5%) | 49 (12.6%) | 152 (10.3%) | |
| Some college (1- to 3-year college or technical school) | 266 (24.6%) | 133 (34.2%) | 399 (27.1%) | |
| College graduate (4-year college) | 352 (32.6%) | 98 (25.2%) | 450 (30.6%) | |
| Graduate degree (e.g., Masters, Doctorate, or professional degree) | 342 (31.6%) | 99 (25.4%) | 441 (30.0%) | |
| Employment status | <0.001 | |||
| Employed full-time | 812 (75.2%) | 244 (62.7%) | 1056 (71.9%) | |
| Employed part-time | 128 (11.9%) | 35 (9.0%) | 163 (11.1%) | |
| Homemaker | 56 (5.2%) | 24 (6.2%) | 80 (5.4%) | |
| Retired | 6 (0.6%) | 0 (0.0%) | 6 (0.4%) | |
| Disabled | 27 (2.5%) | 31 (8.0%) | 58 (3.9%) | |
| Not currently working | 51 (4.7%) | 55 (14.1%) | 106 (7.2%) | |
| Financial toxicity | 28.9 (9.6) | 21.8 (10.7) | 27.0 (10.4) | <0.001 |
“Other” variables include self-reported options that are not accounted for in that category.
UF, uterine fibroid.