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. 2022 Mar 18;13:862394. doi: 10.3389/fendo.2022.862394

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Copyright © 2022 El-Shafey, El-Agawy, Eldosoky, Ebrahim, Elsherbini, El-Sherbiny, Asseri and Elsherbiny

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Representative photomicrographs of NF-κB/p56 immuno-stained cardiac sections from different experimental groups, ×200 bar 50. (B) A graph showing immunoreactive score for NF-κB/p56 cellular expression. Data are represented as mean ± SE, n = 6. **** significance in comparison with control group at p < 0.0001, #### significance in comparison with diabetic group at p < 0.0001, ^~~~~ significance in comparison with DM+Dapa at p < 0.0001, $$$ significance in comparison with DM+Lira group at p < 0.001. (C) A graph showing immunoreactive score for NF-κB/p56 differentially in the nucleus and cytoplasm. Data are expressed as mean ± SEM (n = 6). ^**** p < 0.0001 versus control, ^#### p < 0.0001, ^### p < 0.001 versus diabetic group and p < 0.0001, ^@ p < 0.05 versus DM+Dapa for nuclear expression, ^ΔΔp < 0.01, ^ΔΔΔΔp < 0.0001 versus control, ^ΦΦ p < 0.01 versus diabetic group, ^πππp < 0.001 versus DM+Dapa for cytoplasmic expression. Dapa, dapagliflozin; Lira, liraglutide.