Skip to main content
. 2022 Apr;162(4):1197–1209.e13. doi: 10.1053/j.gastro.2021.12.271

Figure 3.

Figure 3

A common ancestry between cardiac-type and mature intestinal epithelium. (A) H&E of a BE biopsy specimen containing both cardiac and mature intestinal epithelium (outlined region). (B) MUC2+ and MUC2– and (C) MUC5AC+, MUC5AClo, and MUC5AC– glands are present. (D, E) Pre- and post-LCM images, respectively. Gland 1 is a MUC2+MUC5AC– mature intestinal gland. Gland 2 is a MUC2–MUC5AC+ cardiac-type gland. (F, G) Glands 1 and 2 showed a common m.10492T>C mutation in the MT-ND4L region of the mitochondrial genome not present in stroma and other glands.