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. 2022 Apr;162(4):1197–1209.e13. doi: 10.1053/j.gastro.2021.12.271

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© 2022 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

BE gland phenotype diversity is associated with dysplasia. (A) An endoscopic mucosal resection H&E showing an area of high-grade dysplasia (green dashed circle) with surrounding nondysplastic BE showing the presence of multiple gland phenotypes (white dashed box). The inset shows a distinct cardiac-type gland () and a mature intestinal gland (∗) adjacent to each other. (B) and (C) display postesophagectomy BE (neo-BE) biopsy specimens showing cardiac-type epithelium and specialized epithelium, respectively. (Di) The percentage of each phenotype observed in 94 biopsy specimens (from 19 patients) with BE and no history of dysplasia, 47 biopsy specimens (from 12 patients) with nondysplastic BE before developing dysplasia, 33 specimens of EMRs (from 18 patients) with BE adjacent to dysplasia, and 31 neo-BE biopsy specimens (from 19 patients). (Dii) The mean Shannon diversity index per patient for each patient set from Di (∗∗∗ = P < 0.001, NS = not significant).

Inline graphic — BE gland phenotype diversity is associated with dysplasia. (A) An endoscopic mucosal resection H&E showing an area of high-grade dysplasia (green dashed circle) with surrounding nondysplastic BE showing the presence of multiple gland phenotypes (white dashed box). The inset shows a distinct cardiac-type gland () and a mature intestinal gland (∗) adjacent to each other. (B) and (C) display postesophagectomy BE (neo-BE) biopsy specimens showing cardiac-type epithelium and specialized epithelium, respectively. (Di) The percentage of each phenotype observed in 94 biopsy specimens (from 19 patients) with BE and no history of dysplasia, 47 biopsy specimens (from 12 patients) with nondysplastic BE before developing dysplasia, 33 specimens of EMRs (from 18 patients) with BE adjacent to dysplasia, and 31 neo-BE biopsy specimens (from 19 patients). (Dii) The mean Shannon diversity index per patient for each patient set from Di (∗∗∗ = P < 0.001, NS = not significant).