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. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: Environ Int. 2022 Jan 13;160:107054. doi: 10.1016/j.envint.2021.107054

Fig. 3.

Fig. 3.

β regression coefficient estimates according to genes encompassed by DMRs identified as associated with phthalate biomarkers (Šidák-corrected p-value < 0.05, n = 202, 379,904 CpGs). Colors represent genes. Circles represent CpGs mapping to genes within identified DMRs. β coefficient estimates correspond to a change in the DNA methylation level for doubling of the urinary exposure concentration. EWAS regression models, on which the DMR analysis was based, were adjusted for recruitment center, maternal active smoking in the three months preceding pregnancy and during pregnancy, maternal age, parity, maternal education level, maternal pre-pregnancy BMI, season of conception, batch, plate, chip, and estimated placental cell-type proportions. Abbreviations: BMI = body mass index. DMR = differentially methylated region. MBzP = monobenzyl phthalate. MCNP = monocarboxy-iso-nonyl phthalate. MCPP = mono (3-carboxypropyl) phthalate. MECPP = mono(2-ethyl-5-carboxypentyl) phthalate. MEOHP = mono(2-ethyl-5-oxohexyl) phthalate. MEP = monoethyl phthalate. MiBP = mono-iso-butyl phthalate. MnBP = mono-n-butyl phthalate. MEHP = mono(2-ethylhexyl) phthalate.