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IS6110 strain typing analysis of PZA-resistant M. tuberculosis strains. Lanes 1 and 2, strains T63168 and M52997, respectively, which share the same mutation of Gly97→Ser. Lanes 3 and 4, H2374 and H1033, respectively, which share the same mutation of nucleotide G insertion at position 420. Lanes 5 to 8, 10350, 10003, 9155, and 10257, which all share the same pncA mutation profile of an 8-bp deletion at nucleotide position 446 followed by Arg140→Ser.
