Table 3.
Antifungal susceptibility profile of 123 dermatophyte strains to seven antifungal agents by broth microdilution method.
| Dermatophyte species | Antifungal drugs | MIC range (µg/ml) | MIC50/MIC90 (µg/ml) | G mean (µg/ml) | MIC (µg/ml) | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 64 | 32 | 16 | 8 | 4 | 2 | 1 | 0.5 | 0.25 | 0.125 | 0.06 | 0.03 | 0.015 | 0.007 | 0.003 | 0.001 | |||||
| Trichophyton mentagrophytes (n = 6) | TRB | 0.015–16 | 0.09/– | 0.13 | 1 | 2 | 1 | 1 | 1 | |||||||||||
| ITZ | 0.125–8 | 0.75/– | 0.70 | 1 | 2 | 1 | 1 | 1 | ||||||||||||
| KTZ | 0.06–8 | 1.25/– | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||||
| FLZ | 0.125–16 | 1.25/– | 1.2 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||||
| VCZ | 0.125–8 | 0.3/– | 0.5 | 1 | 1 | 1 | 1 | 2 | ||||||||||||
| PCZ | 0.125–16 | 1.25/– | 1.09 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||||
| AMB | 0.125–8 | 0.75/– | 0.79 | 1 | 2 | 1 | 1 | 1 | ||||||||||||
| Trichophyton interdigitale (n = 28) | TRB | 0.003–0.025 | 0.06/0.125 | 0.04 | 7 | 8 | 6 | 4 | 2 | 1 | ||||||||||
| ITZ | 0.03–16 | 0.25/8.8 | 0.38 | 2 | 1 | 2 | 2 | 1 | 4 | 4 | 9 | 2 | 1 | |||||||
| KTZ | 0.03–16 | 0.5/8.8 | 0.37 | 2 | 1 | 2 | 1 | 3 | 6 | 2 | 7 | 2 | 2 | |||||||
| FLZ | 0.125–64 | 0.25/35.2 | 0.78 | 2 | 1 | 2 | 2 | 1 | 1 | 1 | 3 | 4 | 10 | |||||||
| VCZ | 0.125–16 | 0.37/16 | 0.70 | 4 | 3 | 1 | 2 | 4 | 6 | 8 | ||||||||||
| PCZ | 1–16 | 1.5/16 | 1.55 | 6 | 3 | 3 | 2 | 4 | 3 | 2 | 4 | 1 | ||||||||
| AMB | 0.125–8 | 0.25/8 | 0.56 | 5 | 2 | 3 | 3 | 6 | 9 | |||||||||||
| Trichophyton indotineae (n = 10) | TRB | 0.015–32 | 0.125/30.4 | 0.24 | 1 | 1 | 5 | 1 | 1 | 1 | ||||||||||
| ITZ | 0.06–16 | 1/15.2 | 0.9 | 1 | 1 | 1 | 2 | 1 | 3 | 1 | ||||||||||
| KTZ | 0.125–16 | 0.5/16 | 0.79 | 2 | 2 | 2 | 2 | 2 | ||||||||||||
| FLZ | 0.125–16 | 0.75/14.8 | 0.93 | 1 | 3 | 1 | 1 | 2 | 2 | |||||||||||
| VCZ | 0.125–8 | 0.37/7.4 | 0.53 | 1 | 1 | 2 | 1 | 3 | 2 | |||||||||||
| PCZ | 0.125–16 | 0.75/16 | 1 | 2 | 1 | 1 | 1 | 1 | 2 | 2 | ||||||||||
| AMB | 0.125–16 | 0.5/15.2 | 0.81 | 1 | 1 | 1 | 1 | 2 | 3 | 1 | ||||||||||
| Trichophyton rubrum (n = 15) | TRB | 0.003–0.006 | 0.015/0.06 | 0.01 | 3 | 2 | 3 | 2 | 5 | |||||||||||
| ITZ | 0.06–16 | 0.25/14 | 0.30 | 1 | 1 | 1 | 2 | 3 | 2 | 5 | ||||||||||
| KTZ | 0.125–16 | 0.25/16 | 0.75 | 2 | 2 | 1 | 2 | 4 | 4 | |||||||||||
| FLZ | 0.125–16 | 0.5/16 | 1.04 | 3 | 1 | 1 | – | 2 | 2 | 4 | 2 | |||||||||
| VCZ | 0.06–8 | 0.25/5.6 | 0.39 | 1 | 1 | 1 | 1 | 3 | 2 | 5 | 1 | |||||||||
| PCZ | 0.25–16 | 1/16 | 1.58 | 3 | 1 | 1 | 1 | 3 | 4 | 2 | ||||||||||
| AMB | 0.125–8 | 0.5/8 | 0.79 | 3 | 1 | 1 | 2 | 2 | 3 | 3 | ||||||||||
| Trichophyton tonsurans (n = 16) | TRB | 0.003–0.125 | 0.09/0.125 | 0.07 | 8 | 5 | 3 | |||||||||||||
| ITZ | 0.06–8 | 0.37/8 | 0.51 | 2 | 2 | 1 | 1 | 2 | 2 | 4 | 2 | |||||||||
| KTZ | 0.125–16 | 0.5/10.4 | 0.64 | 1 | 2 | 2 | 4 | 5 | 2 | |||||||||||
| FLZ | 0.125–32 | 0.5/20.8 | 0.67 | 1 | 1 | 1 | 2 | 5 | 4 | 2 | ||||||||||
| VCZ | 0.06–16 | 0.25/16 | 0.49 | 3 | 1 | 2 | 3 | 5 | 2 | |||||||||||
| PCZ | 0.125–16 | 0.75/16 | 1.24 | 4 | 2 | 2 | 2 | 3 | 3 | |||||||||||
| AMB | 0.06–16 | 0.25/16 | 0.56 | 3 | 2 | 2 | 3 | 2 | 3 | 1 | ||||||||||
| Trichophyton verrucosum (n = 7) | TRB | 0.06–4 | 0.125/– | 0.16 | 1 | 4 | 2 | |||||||||||||
| ITZ | 0.06–1 | 0.25/– | 0.30 | 2 | 1 | 2 | 1 | 1 | ||||||||||||
| KTZ | 0.125–1 | 0.5/– | 0.37 | 2 | 2 | 1 | 2 | |||||||||||||
| FLZ | 0.125–16 | 0.5/– | 0.90 | 1 | 1 | 1 | 1 | 1 | 2 | |||||||||||
| VCZ | 0.03–16 | 0.5/– | 0.40 | 1 | 1 | 2 | 1 | 1 | 1 | |||||||||||
| PCZ | 0.125–16 | 0.5/– | 1.21 | 2 | 1 | 1 | 2 | 1 | ||||||||||||
| AMB | 0.06–2 | 0.25/– | 0.30 | 1 | 1 | 1 | 1 | 2 | 1 | |||||||||||
| Epidermophyton floccosum (n = 19) | TRB | 0.06–16 | 0.125/0.25 | 0.17 | 1 | 6 | 9 | 3 | ||||||||||||
| ITZ | 0.06–16 | 0.5/16 | 0.80 | 3 | 2 | 1 | 2 | 2 | 5 | 3 | 1 | |||||||||
| KTZ | 0.125–16 | 0.5/16 | 1.07 | 4 | 2 | 1 | 1 | 1 | 3 | 3 | 5 | |||||||||
| FLZ | 0.125–32 | 0.37/32 | 0.77 | 2 | 2 | 1 | 1 | 3 | 7 | 3 | ||||||||||
| VCZ | 0.03–8 | 0.5/8 | 0.80 | 5 | 1 | 2 | 3 | 3 | 4 | 1 | ||||||||||
| PCZ | 0.125–16 | 0.5/16 | 1 | 3 | 2 | 1 | 1 | 2 | 3 | 4 | 3 | |||||||||
| AMB | 0.06–16 | 0.25/16 | 0.57 | 3 | 2 | 4 | 3 | 5 | 2 | |||||||||||
| Microsporum canis (n = 14) | TRB | 0.03–0.125 | 0.09/0.125 | 0.07 | 7 | 5 | 2 | |||||||||||||
| ITZ | 0.03–16 | 0.125/8.5 | 0.19 | 1 | 1 | 1 | 3 | 3 | 4 | 1 | ||||||||||
| KTZ | 0.125–16 | 0.5/20.5 | 0.93 | 2 | 1 | 1 | 3 | 3 | 4 | |||||||||||
| FLZ | 0.125–32 | 0.37/20 | 0.67 | 1 | 2 | 1 | 1 | 2 | 3 | 4 | ||||||||||
| VCZ | 0.125–16 | 0.5/16 | 0.86 | 2 | 1 | 1 | 1 | 3 | 5 | 1 | ||||||||||
| PCZ | 0.125–16 | 1.5/16 | 1.72 | 4 | 1 | 1 | 1 | 1 | 2 | 3 | 1 | |||||||||
| AMB | 0.25–16 | 1/16 | 1.28 | 3 | 1 | 1 | 3 | 2 | 4 | |||||||||||
| Nannizzia gypsea (n = 6) | TRB | 0.015–16 | 0.09/– | 0.13 | 1 | 2 | 1 | 1 | 1 | |||||||||||
| ITZ | 0.125–8 | 0.37/– | 0.70 | 2 | 1 | 1 | 2 | |||||||||||||
| KTZ | 0.125–16 | 0.37/– | 0.89 | 1 | 1 | 1 | 2 | 1 | ||||||||||||
| FLZ | 0.125–16 | 0.62/– | 0.62 | 1 | 1 | 1 | 2 | 1 | ||||||||||||
| VCZ | 0.125–16 | 0.18/– | 0.35 | 1 | 2 | 3 | ||||||||||||||
| PCZ | 0.25–16 | 1.25/– | 1.58 | 3 | 1 | 2 | ||||||||||||||
| AMB | 0.125–8 | 0.37/– | 0.70 | 1 | 1 | 1 | 2 | 1 | ||||||||||||
| Nannizzia fulva (n = 2) | TRB | 0.125–0.25 | –/– | – | 1 | 1 | ||||||||||||||
| ITZ | 0.25–0.5 | –/– | – | 1 | 1 | |||||||||||||||
| KTZ | 0.125–2 | –/– | – | 1 | 1 | |||||||||||||||
| FLZ | 0.25–1 | –/– | – | 1 | 1 | |||||||||||||||
| VCZ | 0.25–0.5 | –/– | – | 1 | 1 | |||||||||||||||
| PCZ | 0.5–1 | –/– | – | 1 | 1 | |||||||||||||||
| AMB | 0.5–1 | –/– | – | 1 | 1 | |||||||||||||||
MIC, minimum inhibitory concentration; TRB, terbinafine; ITZ, itraconazole; KTZ, ketoconazole; FLZ, fluconazole; VCZ, voriconazole; PCZ, posaconazole; AMB, amphotericin B.