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. 2021 Dec 9;107(4):975–979. doi: 10.3324/haematol.2021.279253

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Copyright© 2022 Ferrata Storti Foundation

This article is distributed under the terms of the Creative Commons Attribution Noncommercial License (by-nc 4.0) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

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Figure 2. — The impact of hydroxyurea dose, age at hydroxyurea therapy initiation and the number of pain crises as disease severity marker on the numbers of spermatogonia per round tubular cross-section and fertility index in patients with sickle cell disease. Graphical display of the numbers of spermatogonia per round tubular cross section (S/T) and fertility index (FI) Z-score by hydroxyurea (HU) dose (A and B), age at HU therapy initiation (C and D) and the numbers of pain crises (E and F). In linear regression analysis, the age at HU therapy initiation reached statistical significance. P indicates P-value and r Spearman correlation coefficient.