TABLE 2.
Factors of dementia by using Cox regression with/without Fine and Gray’s competing risk model.
| Competing risk in the model |
||||||||
| Variables | Crude SHR | 95% CI | 95% CI | P | Adjusted SHR | 95% CI | 95% CI | P |
| H1RA | ||||||||
| Without | Reference | Reference | ||||||
| With | 1.129 | 0.549 | 2.901 | 0.672 | 1.025 | 0.883 | 1.297 | 0.274 |
| Gender | ||||||||
| Male | 1.917 | 1.210 | 2.345 | <0.001 | 1.889 | 1.187 | 2.284 | <0.001 |
| Female | Reference | Reference | ||||||
| Age group (year) | ||||||||
| 50–64 | Reference | Reference | ||||||
| ≥65 | 1.988 | 1.469 | 2.486 | <0.001 | 1.782 | 1.368 | 2.168 | <0.001 |
| Insured premium (NT$) | ||||||||
| <18,000 | Reference | Reference | ||||||
| 18,000–34,999 | 0.962 | 0.608 | 1.510 | 0.401 | 0.939 | 0.579 | 1.462 | 0.435 |
| ≥35,000 | 0.907 | 0.511 | 1.439 | 0.477 | 0.880 | 0.482 | 1.380 | 0.501 |
| CCI_R group | ||||||||
| 0 | Reference | Reference | ||||||
| 1–3 | 1.209 | 1.030 | 1.492 | 0.021 | 1.189 | 0.997 | 1.402 | 0.054 |
| ≥4 | 1.428 | 1.258 | 1.688 | <0.001 | 1.352 | 1.173 | 1.579 | <0.001 |
| Season | ||||||||
| Spring | Reference | Reference | ||||||
| Summer | 1.065 | 0.709 | 1.548 | 0.462 | 1.061 | 0.692 | 1.531 | 0.475 |
| Autumn | 1.138 | 0.803 | 1.703 | 0.352 | 1.129 | 0.757 | 1.684 | 0.367 |
| Winter | 1.142 | 0.811 | 1.711 | 0.348 | 1.137 | 0.761 | 1.699 | 0.362 |
| Location | ||||||||
| Northern Taiwan | Reference | Multicolline arity with urbanization level | ||||||
| Middle Taiwan | 0.923 | 0.578 | 1.352 | 0.420 | Multicolline arity with urbanization level | |||
| Southern Taiwan | 0.984 | 0.624 | 1.397 | 0.387 | Multicolline arity with urbanization level | |||
| Eastern Taiwan | 0.863 | 0.488 | 1.262 | 0.612 | Multicolline arity with urbanization level | |||
| Outlets islands | 0.557 | 0.178 | 3.972 | 0.883 | Multicolline arity with urbanization level | |||
| Urbanization level | ||||||||
| 1 (The highest) | 1.431 | 0.928 | 1.942 | 0.250 | 1.309 | 0.813 | 1.872 | 0.272 |
| 2 | 1.309 | 0.815 | 1.925 | 0.299 | 1.238 | 0.792 | 1.824 | 0.331 |
| 3 | 1.104 | 0.612 | 1.720 | 0.348 | 1.031 | 0.519 | 1.680 | 0.399 |
| 4 (The lowest) | Reference | Reference | ||||||
| Level of care | ||||||||
| Hospital center | 1.697 | 1.301 | 2.630 | <0.001 | 1.488 | 1.124 | 2.525 | <0.001 |
| Regional hospital | 1.632 | 1.225 | 2.591 | <0.001 | 1.430 | 1.110 | 2.517 | <0.001 |
| Local hospital | Reference | Reference | ||||||
P, Chi-square/Fisher exact test on category variables and t-test on continue variables; H1RA, histamine receptor type 1 antagonist; CI, confidence interval, adjusted SHR, adjusted sub-distribution hazard ratio, adjusted variables listed in the table, NT$, New Taiwan Dollars, CCI_R, Charlson Comorbidity Index, dementia removed.