TABLE 3.
Factors of dementia in different model by using Cox regression with/without Fine and Gray’s competing risk model.
| Model | H1RA |
Competing risk in the model |
|||||||
| Subgroups | Populations | Events | PYs | Rate (per 105 PYs) | Adjusted HR | 95% CI | 95% CI | P | |
| Model 1 | Without | 26,958 | 1,314 | 264,188.40 | 497.37 | Reference | |||
| H1RA subgroup | With | 8,986 | 443 | 87,343.93 | 507.19 | 1.025 | 0.883 | 1.297 | 0.274 |
| G1 H1RA | 6,975 | 345 | 67,784.05 | 508.97 | 1.029 | 0.888 | 1.304 | 0.260 | |
| G2 H1RA | 2,011 | 98 | 19,559.88 | 501.03 | 1.013 | 0.872 | 1.265 | 0.279 | |
| Model 2 | Without, 0 | 26,958 | 1,314 | 264,188.40 | 497.37 | Reference | |||
| DDD | 1–364 | 2,731 | 135 | 26,549.41 | 508.49 | 1.028 | 0.886 | 1.328 | 0.271 |
| 365–1,459 | 3,865 | 189 | 37,568.23 | 503.08 | 1.017 | 0.881 | 1.359 | 0.284 | |
| ≥1,460 | 2,390 | 119 | 23,226.29 | 512.35 | 1.035 | 0.906 | 1.384 | 0.249 | |
P, Chi-square/Fisher exact test on category variables and t-test on continue variables; H1RA, histamine type 1 antagonist; PYs, Person-years; G1 H1RA, First-Generation 1 histamine type 1 antagonist, G2 H1RA, Second-Generation histamine type 1 antagonist; Adjusted HR, Adjusted sub-distribution hazard ratio: Adjusted for the variables listed in Table 1. CI, confidence interval; DDD, daily dose defined.