Table 4.
Non-Parametric Estimate of the Probability of Remaining Free of Experiencing DLT According to Cycle of Therapy Received
| Reporting Period | Number of Patients Who Received Therapy | Number of Patients Who Experienced DLT | Estimated Probability of Remaining Free of DLT from The Start of Therapy Through the Noted Reporting Period |
|---|---|---|---|
| Radiation therapy and Vorinostat | 70 | 10 | 0.8571 |
| Maintenance Vorinostat Cycles 1 and 2 | 59 | 12 | 0.6828 |
| Maintenance Vorinostat Cycles 3 and 4 | 39 | 5 | 0.5953 |
| Maintenance Vorinostat Cycles 5 and 6 | 26 | 2 | 0.5495 |
| Maintenance Vorinostat Cycles 7 and 8 | 14 | 1 | 0.5102 |
| Maintenance Vorinostat Cycles 9 and 10 | 5 | 1 | 0.4082 |
| Maintenance Vorinostat Cycles 11 and 12 | 3 | 0 | 0.4082 |
For example, it is estimated that 40.8% (100 x 0.4082) of patients will complete maintenance vorinostat through cycle 9 and 10 without experiencing any DLT.