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. 2022 Mar 16;144(12):5284–5294. doi: 10.1021/jacs.1c07675

Figure 1.

Figure 1

(a) Electrostatic potential surface of the Fab region of a thiomab derived from trastuzumab (Thiomab Tras-LC-V205C) and the corresponding mutant (Fab-V205C/K207A). (b) Linkers studied in this work were based on acetals.