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. 2022 Mar 16;144(12):5284–5294. doi: 10.1021/jacs.1c07675

Figure 4.

Figure 4

(a) Stability (in the reaction medium) of acetals 2 and 3 conjugated to different antibodies. (*) =25 °C, pH 7, 24 h. (b) Hydrolysis of acetal in IgG-2, as determined by the ESI–MS, showing the combined ion series (top) and the deconvoluted mass spectrum (bottom). Conditions: reaction medium (25 °C, pH 7, 24 h). Representative snapshots derived from 0.5 μs MD simulations performed on Fab-2. (c) or Fab-3 (d). The R configuration at both stereocenters of the linker was considered in the calculations performed on Fab-3.