Table 3.
Variables Associated With Treatment Discontinuation for Inefficacy or Adverse Event
Variable | Univariable Cox Regression | Multivariable Cox Regression | ||||
---|---|---|---|---|---|---|
Hazard Ratio | 95% CI | P | Hazard Ratio | 95% CI | P | |
Disease duration | 1.01 | 0.97–1.05 | 0.638 | |||
Duration of prior IFX exposure | 0.99 | 0.90–1.09 | 0.884 | |||
Clinical remission at index switch | 0.33 | 0.15–0.75 | 0.008 | 0.51 | 0.33–0.78 | 0.002 |
Immunomodulator at index switch | 0.61 | 0.26–1.42 | 0.250 | |||
UC versus CD | 1.27 | 0.78–2.09 | 0.339 | |||
Patient group | ||||||
Originator to CT-P13 | 1 | 1 | ||||
Originator to CT-P13 to SB2 | 0.39 | 0.14–1.11 | 0.077 | 0.33 | 0.11–0.94 | 0.038 |
CT-P13 to SB2 | 0.42 | 0.16–1.12 | 0.083 | 0.27 | 0.10–0.78 | 0.015 |