FIG. 1.

Effects of a single dose (a) or double doses (b) of PEG-AMB-LIP versus multiple doses of AMB desoxycholate (c) on survival of persistently leukopenic rats with pulmonary aspergillosis (Kaplan-Meier plot). Leukopenic rats were inoculated in the left lobe of the lung with 2 × 10⁴ A. fumigatus conidia at time zero. Groups of 15 animals each were treated intravenously with PEG-AMB-LIP as a single dose of 10 mg of AMB/kg (■), a double dose (given every 72 h) of 10 mg of AMB/kg/dose (⧫) or a double dose (given every 72 h) of 14 mg of AMB/kg/dose (▴); AMB desoxycholate was administered for 10 consecutive days at 1 mg of AMB/kg/dose (●). Controls were treated with placebo liposomes (▵) or 5% glucose (○) or were left untreated (▿). Treatment was started 30 h after fungal inoculation, at which time mycelial growth was firmly established. ⧣, P ≤ 0.05; and ∗, P ≤ 0.005, versus untreated or placebo-treated rats.