TABLE 1.
Effects of a single dose or double doses of PEG-AMB-LIP versus multiple doses of AMB desoxycholate on presence of viable A. fumigatus in the left lung and dissemination to the right lung and liver at the time of death in persistently or temporarily leukopenic ratsa
| Treatmentb | Daily dose of AMB (mg/kg) | No. of doses (dosing interval [h]) | No. of culture-positive organsc/total no. of ratsd
|
|||||
|---|---|---|---|---|---|---|---|---|
| Left lung
|
Right lung
|
Liver
|
||||||
| P | T | P | T | P | T | |||
| Untreated | 15/15 | 15/15 | 14/15 | 12/15 | 10/15 | 9/15 | ||
| PEG-AMB-LIP | 10 | 1 | 15/15 | 15/15 | 13/15 | 12/15 | 1/15e | 2/15f |
| PEG-AMB-LIP | 10 | 2 (72) | 15/15 | 15/15 | 9/15 | 8/15 | 0/15e | 0/15e |
| PEG-AMB-LIP | 14 | 2 (72) | 15/15 | 15/15 | 9/15 | 8/15 | 0/15e | 0/15e |
| AMB desoxycholate | 1 | 10 (24) | 15/15 | 15/15 | 9/15f | 6/15e | 1/15e | 1/15e |
| Placebo liposomes | 2 (72) | 15/15 | 15/15 | 12/15 | 12/15 | 11/15 | 8/15 | |
| Placebo (glucose) | 10 (24) | 15/15 | 15/15 | 15/15 | 14/15 | 10/15 | 8/15 | |
a
Leukopenic rats were inoculated in the left lung at time zero with 2 × 104 A. fumigatus conidia.
b
PEG-AMB-LIP, AMB desoxycholate, or placebo treatment was administered intravenously.
c
Effect of treatment was determined by postmortem cultures.
d
P, persistent leukopenia; T, temporary leukopenia.
e
P ≤ 0.005 versus placebo treatment.
f
P ≤ 0.05 versus placebo treatment.