. 2021 Nov 1;24(4):516–527. doi: 10.1093/neuonc/noab252

Table 3.

European and North American Concepts for Radiotherapy

	Europe (SIOP)	North America (COG)
Pure germinoma	M0 Chx, WVI24Gy, F-RT/boost 16Gy; if CR no boost (currently under evaluation) M+ RT CSI alone 24Gy, IF-RT/boost 16Gy^42,43	M0 ACNS1123: Chx WVI 18Gy, IF-RT/boost 12Gy for CR; WVI 24Gy, IF-RT/boost 12Gy if no CR is currently under evaluation
NGGCT	M0 Chx, IF-RT 54Gy (surgery if not CR before RT) M+ Chx, CSI 30Gy, IF-RT/boost 24Gy²⁹	M0 ACNS0122:Chx, CSI 36Gy, boost 18Gy ACNS1123: Chx, WVI/30.6Gy, boost 23.4Gy M+ ACNS0122: CSI 36Gy, boost 18Gy^28,39
Teratoma	No detailed recommendations (register)	No detailed recommendations

Abbreviations: Chx: chemotherapy; CSI: craniospinal irradiation; F-RT: focal irradiation; NGGCT: non-germinomatous germ cell tumors; WVI, whole ventricular irradiation.