Table 4.
Strategy for Non-Germinomatous Intracranial Germ Cell Tumors
| Patterns of Relapse | |||||||
|---|---|---|---|---|---|---|---|
| Study | Treatment | PFS (5 y) | OS (5 y) | Local | Distant | Combined | Markers Alone |
| ACNS0122 (N = 48) | Induction (6 cycles) Carboplatin/Etoposide alternating with ifosfamide/etoposide Followed by CSI (36Gy) plus tumor bed boost (54Gy) |
92% | 98% | 9 | 4 | 0 | 2 |
| SIOP’96(N = 116) | Induction (4 cycles) With cisplatin, etoposide, and ifosfamide Followed by IF-RT (54Gy) |
72% | 82% | 14 | 9 | 6 | 0 |
| ACNS1123 (N = 66 CR/PR) |
Induction (6 cycles) Carboplatin/etoposide alternating with ifosfamide/etoposide Followed by WVI (30.6Gy) plus tumor bed boost (54Gy) |
88% (4 y) | 92% (4 y) | 0 | 7 | 1 | 0 |
Abbreviations: CR, complete response; CSI, craniospinal irradiation; IF, involved field; M0, localized disease; OS, overall survival; PFS, progression-free survival; PR, partial response; WVI, whole ventricular irradiation.