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. 2022 Mar 22;25(5):180. doi: 10.3892/mmr.2022.12696

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Copyright: © Gao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — PIC inhibits the progression and reduces the arthritis scores of rheumatoid arthritis. (A) Development of CIA was inhibited by treatment with PIC. Scale bar, 1 cm. (B) Differences in arthritis scores between CIA + PIC-treated, CIA and control rats. (C) Levels of IL-1β, IL6 and TNF-α. (D) Immunohistochemical staining of joint tissue sections of MMP13 (arrow). (E) Expression of MMP-13 in cartilage tissue. Scale bar, 100 µm. (F) MMP-13-positive cell rate. n=8 rats/group. ^##P<0.01 vs. control; and **P<0.01 vs. CIA. PIC, piceatannol; CIA, collagen-induced arthritis.