Table 3.
Predictors of OS at Univariate and Multivariate Analyses
| Variable | Univariate Analysis | Multivariate Analysis | ||||
|---|---|---|---|---|---|---|
| Odds Ratio | 95% CI | P-value | Odds Ratio | 95% CI | P-value | |
| Age (yr) | 1.017 | 0.977-1.058 | .42 | |||
| Sex | ||||||
| Male | 1 | 1 | ||||
| Female | 0.40 | 0.16-0.98 | .045 | 0.22 | 0.14-0.88 | .42 |
| Tumor side | ||||||
| Left | 1 | |||||
| Right | 1.15 | 0.46-2.85 | .80 | |||
| Tumor site | ||||||
| Frontal | 1 | |||||
| Parietal | 1.74 | 0.48-6.38 | .40 | |||
| Temporal | 1.50 | 0.41-5.51 | .50 | |||
| Insula | 0.58 | 0.07-4.62 | .60 | |||
| Preoperative KPS | 0.98 | 0.89-1.08 | .70 | |||
| Preoperative tumoral volume, cm3 Continuous variable |
1..02 | 1.01-1.03 | .001 | 1.03 | 1.01-1.05 | .006 |
| Preoperative tumoral volume, cm3 | ||||||
| 0-15 | 1 | |||||
| 15-30 | 0.58 | 0.06-5.18 | .60 | |||
| >30 | 4.47 | 1.44-13.8 | .009 | |||
| % EOR Continuous variable |
0.97 | 0.94-1.0 | .037 | 0.95 | 0.90-1.01 | .12 |
| Postoperative RTV cm3 Continuous variable |
1.03 | 1.00-1.06 | .083 | |||
| Postoperative RTV cm3 | ||||||
| Supratotal and complete resection | 1 | 1 | ||||
| RTV ≥1 cm3 | 2.93 | 1.00-8.60 | .050 | 1.09 | 0.27-4.36 | .95 |
| Molecular class | ||||||
| Oligodendroglioma | 1 | |||||
| Diffuse astrocitoma IDH1/2 mutated | 2 | 0.74-5.43 | .20 | |||
| Early adjuvant treatment after surgery | ||||||
| Yes vs No | 0.99 | 0.67-5.43 | .19 |
Abbreviations: CI, confidence interval; EOR, extent of resection; MRI, magnetic resonance imaging; P-value, level of marginal significance; RTV, residual tumor volume.
Table showing the influence of different factors on the OS rates as per univariate survival analysis and multivariate analysis (P < .05 at log-rank test). Bold values represent statistical significant results (P < .05). Tumor volume analysis was performed on 3D T2-FLAIR MRI. Patients belonging to IDH1/2 wild-type molecular class were not included in survival analysis because no deaths occurred in this subgroup.