Table 4.
Predictors of Tumor Recurrence at Univariate and Multivariate Analyses
| Variable | Univariate Analysis | Multivariate Analysis | ||||
|---|---|---|---|---|---|---|
| Odds Ratio | 95% CI | P-value | Odds Ratio | 95% CI | P-value | |
| Age (yr) | 1.00 | 0.98-1.03 | .50 | |||
| Sex | ||||||
| Male | 1 | |||||
| Female | 0.94 | 0.64-1.38 | .70 | |||
| Tumor side | ||||||
| Left | 1 | |||||
| Right | 0.71 | 0.48-1.04 | .075 | |||
| Tumor site | ||||||
| Frontal | 1 | |||||
| Parietal | 1.16 | 0.56-2.43 | .70 | |||
| Temporal | 1.52 | 0.77-3.0 | .20 | |||
| Insula | 1.73 | 0.85-3.50 | .13 | |||
| Preoperative KPS | 1.04 | 0.98-1.10 | .20 | |||
| Preoperative tumoral volume, cm3 Continuous variable |
1.02 | 1.00-1.02 | .006 | 1.0 | 0.99-1.01 | .5 |
| Preoperative tumoral volume, cm3 | ||||||
| 0-15 | ||||||
| 15-30 | 1.62 | 0.99-2.64 | .053 | |||
| >30 | 1.31 | 0.72-2.42 | .10 | |||
| % EOR Continuous variable |
1.00 | 0.98-1.02 | .90 | |||
| Postoperative RTV cm3 Continuous variable |
||||||
| Postoperative RTV cm3 | 1.02 | 1.0-1.05 | .074 | |||
| Supratotal and complete resection | 1 | |||||
| RTV ≥1 cm3 | 0.95 | 0.63-1.43 | .8 | |||
| Molecular class | ||||||
| Oligodendroglioma | 1 | |||||
| Diffuse astrocytoma IDH1/2 mutated | 1.39 | 0.85-2.28 | .20 | |||
| Time of surgery | ||||||
| </= 6 months | 1 | 1 | ||||
| >6 months | 1.62 | 1.03-2.53 | .036 | 1.67 | 1.03-2.63 | .028 |
Abbreviations: CI, confidence interval; EOR, extent of resection; MRI, magnetic resonance imaging; P-value, level of marginal significance; RTV, residual tumor volume.
Table showing the influence of different factors on the OS rates as per univariate survival analysis and multivariate analysis (P < .05 at log-rank test). Bold values represent statistical significant results (P < .05). Tumor volume analysis was performed on 3D T2-FLAIR MRI.