Table 4:
Meta-analyses for early mortality and morbidity in AD-A and AD-B
| Cohort | Outcome | Males (95% CI) | I 2 (%), Q-testa | Females (95% CI) | I 2, Q-testa | RR male vs female (95% CI) | P-value RR | I 2 (%), Q-testa | Studies |
|---|---|---|---|---|---|---|---|---|---|
| AD-A | Early mortality all diagnosed patients (%) | 36.9 (25.9–52.6) | 90.9, <0.001 | 52.6 (34.6–80.1) | 92.9, <0.001 | 0.78 (0.66–0.93) | 0.006 | 0.0, 0.723 | 3 |
| AD-A | Early mortality surgical patients (%) | 16.8 (13.7–20.6) | 83.2, <0.001 | 19.3 (14.1–26.4) | 89.5, <0.001 | 0.94 (0.84–1.06) | 0.308 | 0.0, 0.718 | 10 |
| AD-A | Early mortality surgical patients (%) (sensitivity 1)b | 19.8 (16.6–23.6) | 78.1, <0.001 | 23.4 (17.4–31.3) | 87.5, <0.001 | 0.94 (0.84–1.05) | 0.282 | 0.0, 0.731 | 7 |
| AD-A | Early mortality surgical patients (%) (sensitivity 2)c | 14.8 (12.1–18.0) | 73.8, <0.001 | 14.9 (11.2–19.7) | 79.8, <0.001 | 1.00 (0.88–1.13) | 0.965 | 0.0, 0.982 | 7 |
| AD-A | Early mortality surgical patients (%) (sensitivity 3)d | 14.6 (11.4–18.7) | 83.4, <0.001 | 14.8 (9.7–22.5) | 91.4, <0.001 | 0.95 (0.84–1.08) | 0.450 | 0.0, 0.515 | 6 |
| AD-A | Stroke (%) | 13.1 (10.2–16.8) | 54.1, 0.069 | 12.7 (9.16–17.8) | 59.7, 0.042 | 0.99 (0.79–1.23) | 0.911 | 0.0, 0.904 | 5 |
| AD-A | Acute renal failure (%) | 17.1 (12.2–24.0) | 82.3, <0.001 | 12.3 (8.5–17.9) | 68.0, 0.010 | 1.24 (0.93–1.66) | 0.135 | 19.5, 0.286 | 5 |
| AD-A | Re-exploration for bleeding (%) | 18.1 (12.9–25.3) | 81.0, <0.001 | 12.9 (8.7–19.2) | 65.8 <0.02 | 1.34 (1.08–1.67) | 0.010 | 0.0, 0.645 | 5 |
| AD-B | Early mortality all diagnosed patients (%) | 9.46 (6.56–13.6) | 76.2, 0.015 | 11.6 (10.7–12.6) | 0.0, 0.426 | 0.92 (0.83–1.03) | 0.143 | 0.0, 0.543 | 3 |
| AD-B | Early mortality surgicallye treated patients (%) | 6.21 (0.45–85.7) | 92.6, 0.001 | 11.4 (3.05–42.3) | 65.8, 0.088 | 0.77 (0.26–2.31) | 0.637 | 27.2, 0.241 | 2 |
a
The P-value of the Q-test is reported.
b
Exclusion of studies performed in Asia: Fukui et al. [6], Maitusong et al. [27] and Suzuki et al. [23].
c
Exclusion of studies which included all diagnosed patients: Nienaber et al. [5], Maitusong et al. [25], Pourafkari et al. [20], leaving studies which included only surgical patients.
d
Inclusion of studies with a good study quality.
e
Surgical treatment included open surgical repair and endovascular treatment.
AD-A: acute type A aortic dissection; AD-B: acute type B aortic dissection; CI: confidence interval; RR: risk ratio.