TABLE 1.
Characteristics of the studies included in this meta-analysis.
| Study ID | N(E/C) | Sex(M/F) | Age(years) | APACHE II score | Therapy of experiment group | Therapy of control group | Course(day) | Outcomes |
|---|---|---|---|---|---|---|---|---|
| Zhang et al. (2011) | 36/32 | 38/30 | E:49.3±15.5 C:50.5±17.2 | E:17.58±5.77 C:18.28±5.66 | Shenfu 100ml qd+WM | WM | 7 | ② |
| Pan (2011) | 32/22 | 31/23 | E:54.44±3.20 C:52.05±3.59 | / | Shenqifuzheng 250ml qd+WM | WM | 14 | ① |
| Qiu et al. (2012) | 36/32 | 38/30 | E:49.8±10.1 C:50.3±10.18 | E:17.58±5.77 C:18.28±5.66 | Shenfu 100ml qd+WM | WM | 7 | ① ④ ⑤ ⑦ ⑧ ⑨ |
| Zheng and Pan (2014) | 38/40 | 42/36 | E:70.25±9.56 C:69.48±10.13 | E:17.67±5.94 C:18.02±6.13 | Shenfu 100ml qd+WM | WM | 7 | ① ② |
| Ren et al. (2014) | 30/30 | 45/15 | E:66.03±15.67 C:70.43±12.46 | E:19.00±6.32 C:18.07±5.93 | Huangqi injection 60ml qd+WM | WM | 7 | ① ② ⑩ |
| Qin (2014) | 34/34 | 40/28 | E:49.1±13.6 C:50.5±16.3 | / | Shengmai 60ml qd+WM | WM | 7 | ③ ④ ⑥ ⑩ |
| Yao (2015) | 20/20 | 25/15 | E:63.3±11.4 C:63.2±6.6 | E:28.6±2.2 C:27.2±2.3 | Shenfu 100ml qd+WM | WM | 15 | ① |
| Zhang Z. Y. et al. (2015) | 20/20 | 21/19 | E:62.6±14.0 C:63.1±13.6 | / | Shenqifuzheng 250ml qd+WM | WM | 7 | ① ⑤ ⑥ ⑦ ⑧ ⑨ |
| Huang (2015) | 30/30 | 40/20 | E:76.63±7.80 C:75.47±9.07 | E:18.23±5.77 C:16.90±5.10 | Shenfu 40ml qd+WM | WM | 7 | ① ② ③ |
| Liu and Yang (2018) | 31/31 | 37/25 | E:47.7±6.3 C:47.6±6.2 | E:20.767±3.7 C:20.751±3.6 | Shenmai 20-100ml qd+WM | WM | 7 | ③ ④ ⑥ ⑦ ⑧ |
| Li et al. (2021) | 38/38 | 41/35 | E:65.27±8.54 C:65.89±8.76 | / | Shenfu 100ml qd+WM | WM | 7 | ④ ⑤ ⑥ ⑩ |
| Zhou et al. (2016) | 33/32 | 35/30 | E:63±4 C:64±3 | E:20.1±1.0 C:19.1±1.2 | Shenfu 120ml /+WM | WM | 14 | ③ |
| Wang and Wu (2016) | 48/48 | 61/35 | E:69.15±5.24 C:68.94±5.17 | E:29.02±3.25 C:28.94±3.18 | Shenmai 60ml q12h+WM | WM | 7 | ① ③ ④ ⑥ |
| Zhao et al. (2016) | 35/35 | 37/33 | E:72.6±10.3 C:74.8±12.9 | / | Huangqi injection 20ml qd+WM | WM | 14 | ⑥ |
| Wang et al. (2016) | 30/30 | 33/27 | E:52.9±5.6 C:52.8±5.8 | / | Shengmai 60ml qd+WM | WM | 7 | ⑤ ⑥ |
| Hu et al. (2016) | 35/35 | 40/30 | E:57.5±7.1 C:56.7±6.9 | / | Shengmai 60ml qd+WM | WM | 7 | ⑥ |
| Zhang (2017) | 36/35 | 39/32 | E:71.43±9.21 C:69.37±10.35 | E:25.78±6.89 C:25.11±7.13 | Shenfu 100ml qd+WM | WM | 7 | ① |
| Lu et al. (2017) | 20/20 | 21/19 | E:52.2±16.4 C:49.3±16.5 | E:17.10±4.0 C:17.9±4.1 | Shenmai 100ml qd+WM | WM | 7 | ① ③ ④ |
| Jin et al. (2017) | 37/37 | 47/27 | E:56.4±4.6 C:55.8±5.1 | E:20.6±3.5 C:20.9±3.7 | Shenqifuzheng 250ml qd+WM | WM | 7 | ① ⑤ ⑥ |
| Zhu (2017) | 19/20 | 18/21 | E:72.63±10.25 C:77.85±15.31 | E:17.79±8.48 C:19.45±7.88 | Shenfu 50ml Bid+WM | WM | 7 | ① ② ③ ④ ⑦ ⑧ ⑨ |
| Cheng et al. (2018) | 34/34 | 44/24 | E:56.65±8.17 C:57.33±7.29 | E:25.77±6.83 C:26.14±5.77 | Shenfu 100ml qd+WM | WM | 7 | ① ③ ⑤ ⑥ |
| Liu et al. (2018) | 39/39 | 40/38 | E:61.72±11.43 C:62.71±12.45 | / | Shenfu 100ml Bid+WM | WM | 7 | ③ |
| Yan (2018) | 25/25 | / | E:65.51±1.62 C:65.44±1.74 | / | Shenfu 100ml qd+WM | WM | 7 | ③ ⑤ ⑥ |
| Li (2018) | 31/31 | 33/29 | 55.3±12.1 | / | Shenqifuzheng 100ml qd+WM | WM | 7 | ④ ⑦ ⑧ ⑨ |
| Li et al. (2019) | 32/32 | 37/27 | E:49.1±15.7 C:49.2±15.4 | E:17.57±5.76 C:18.27±5.65 | Shenfu 100ml qd+WM | WM | 7 | ① |
| Li et al. (2019) | 25/25 | 30/20 | E:67.64±14.49 C:68.84±15.80 | E:25.28±7.33 C:24.68±6.19 | Shenfu 60ml qd+WM | WM | 7 | ① ② ⑤ ⑥ |
| Pan and Chen (2020) | 35/35 | 44/26 | E:51.63±6.50 C:51.20±6.14 | / | Shenfu 60ml qd+WM | WM | 7 | ③ ④ |
| Lei and Li (2016) | 30/30 | 31/29 | E:65.4±13.1 C:64.5±12.2 | E:21.3±7.3 C:20.4±6.9 | Shenfu 100ml qd+WM | WM | 7 | ② |
| Zhou (2014) | 30/30 | 33/27 | E:70.15±3.45 C:69.43±2.84 | E:21.17±2.92 C:20.65±2.63 | Shenfu 100ml qd+WM | WM | 7 | ① ② |
| Chen et al. (2015) | 20/20 | 24/16 | E:50.5±10.5 C:54.6±14.2 | E:19.6±4.6 C:18.1±4.3 | Shenfu 60ml qd+WM | WM | 7 | ① ③ ④ ⑥ ⑦ ⑧ ⑨ |
| Zhou et al. (2015) | 32/32 | 35/29 | E:53.96±10.55 C:50.32±13.74 | / | Shenfu 100ml qd+WM | WM | 7 | ② ⑤ ⑥ |
| Cui and Dai (2016) | 40/40 | 44/36 | E:58.2±12.0 C:59.1±10.4 | E:28.5±3.4 C:27.8±2.9 | Shenfu 100ml q12h+WM | WM | 7 | ① ② |
| Huang (2016) | 20/20 | 24/16 | E:55±6 C:57±8 | E:25±5 C:26±7 | Shenfu 100ml qd+WM | WM | 7 | ② |
| Zhang and Zhang (2019) | 67/67 | 72/62 | E:45.3±2.5 C:49.6±2.1 | E:18.73±2.54 C:19.21±2.76 | Shenfu 200ml qd+WM | WM | 7 | ① |
| Zhang (2019) | 24/24 | 19/29 | E:73.33±14.23 C:76.33±13.31 | E:21.46±0.43 C:21.42±0.43 | Shenfu 60ml qd+WM | WM | 7 | ① ② ③ ④ ⑩ |
| Zhang (2019) | 24/25 | 27/22 | E:73.33±14.23 C:76.28±15.85 | E:21.46±0.43 C:21.84±0.42 | Shengmai 40ml qd+WM | WM | 7 | ① ② ③ ④ ⑩ |
| Huang et al. (2010) | 30/30 | 35/25 | E:61.5±8.7 C:60.8±9.2 | E:20.43±6.26 C:20.07±6.33 | Shenmai 50ml q12h+WM | WM | 7 | ① ⑤ ⑥ |
| Ning (2011) | 30/30 | 39/21 | 56.9±2.3 | E:21.0±3.5 C:21.0±3.7 | Shenmai 60ml qd+WM | WM | 7 | ① |
| Ning XP 2012 | 30/30 | 35/25 | 58.2±3.6 | / | Shenmai 60ml qd+WM | WM | 7 | ⑥ |
| Shen et al. (2014) | 23/23 | 40/6 | E:67.2±8.1 C:65.5±7.9 | / | Shenmai 100ml qd+WM | WM | 7 | ① ⑦ ⑧ ⑨ |
| Xu et al. (2015) | 40/40 | 44/36 | 60.8±9.0 | / | Shenmai 10ml/h 24h+WM | WM | 7 | ③ ④ ⑤ ⑥ |
| Zhang (2016) | 72/72 | 95/49 | E:65.87±17.28 C:64.35±18.19 | E:21.31±5.31 C:21.89±5.28 | Shenmai 100ml qd+WM | WM | 7 | ① |
| Zhang and Wang (2017) | 41/41 | 47/35 | E:51.32±4.57 C:50.89±5.18 | / | Shenmai 60ml qd+WM | WM | 7 | ③ ⑦ ⑨ |
| Feng (2019) | 33/33 | 37/29 | E:62.14±18.72 C:61.78±17.33 | E:21.56±2.04 C:22.53±2.42 | Shenmai 10ml/h 24h+WM | WM | 7 | ① ④ ⑤ ⑥ |
| Chen T. F. et al. (2020) | 28/34 | 38/24 | E:73.33±14.23 C:76.28±15.94 | / | Shenmai 100ml q12h+WM | WM | 14 | ③ ④ |
| Liu and Zhang (2013) | 30/30 | 39/21 | E:48.9±5.2 C:50.2±4.9 | / | Shengmai 20ml-60ml qd+WM | WM | 7 | ③ ④ ⑥ |
| Ai et al. (2013) | 30/30 | 37/23 | E:55.87±13.14 C:56.53±11.17 | E:20.07±4.68 C:19.47±4.75 | Shenqifuzheng 250ml qd+WM | WM | 7 | ① ③ ④ ⑦ ⑧ ⑨ |
| Ma et al. (2018) | 47/48 | 61/34 | E:66.4±8.7 C:65.5±9.0 | E:17.2±2.3 C:17.5±2.4 | Shenqifuzheng 250ml qd+WM | WM | 7 | ① ⑦ ⑧ ⑨ |
| Ren et al. (2013) | 30/30 | 45/15 | E:66.0±15.7 C:70.4±12.5 | E:19.0±6.3 C:18.1±5.9 | Huangqi injection 60ml qd+WM | WM | 7 | ③ ④ ⑤ ⑩ |
| Chen (2008) | 30/20 | 35/15 | E:73.80±9.50 C:75.35±10.18 | / | Huangqi injection 30ml q12h+WM | WM | 14 | ① ⑤ ⑥ ⑦ ⑧ ⑨ |
| Zhang et al. (2017) | 78/79 | 88/69 | E:59.3±16.4 C:58.6±17.2 | E:18.6±6.8 C:18.3±6.5 | Shenfu 100ml qd+WM | WM | 7 | ① ② |
Note: ①APACHE II score; ②28-day mortality; ③The level of PCT; ④The level of CRP; ⑤IL-6; ⑥TNF-α; ⑦CD4+; ⑧CD8+; ⑨CD4+/CD8+; ⑩ADRs/ADEs.