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. 2022 Apr 1;18:124. doi: 10.1186/s12917-022-03217-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — S protein cleavage site and catalytic residues of the TMPRSS2 enzyme are conserved. A S protein sequence alignment at the site where human TMPRSS2 cleaves the SARS-CoV-2 spike protein. The TMPRSS2 enzyme cleaves between the arginine (R) and serine (S) residues. Only the FIP virus has a glycine (G) in place of the arginine (R) residue. Aligned protein sequences of the substrate binding site (B) and active site (C) of the TMPRSS2 enzyme of various host species are shown. Arrows in panel C point to the triad of catalytic residues histidine (H) 296, aspartic acid (D) 345 and serine (S) 441 that are essential for binding to the SARS-CoV-2 S protein. All conserved residues are shaded blue, and sequence consensus conservation is shown as colored bars (red, tall bars mean more conserved). The threshold for showing a consensus is set at > 70 for A and > 50% for B and C. The letter X denotes no consensus, and amino acids are listed in single letter codes