TABLE 2.
Incidence of co-occurrence of mutations 44D/A and 118 (either singly or together in an isolate) with ZDV resistance-associated mutations 41L, 67N, 70R, 210W, 215Y/F, and 219Q/E and with 3TC resistance-associated mutation 184V in RT in clinical HIV-1 isolatesa
| Status of ZDV resistance-associated positions | Status of 3TC resistance-associated position 184 | No. (%) of isolates with the following mutation(s):
|
||
|---|---|---|---|---|
| 44D/A | 118I | 44D/A + 118I | ||
| Wild type | Wild type | 3 (1.54) | 33 (7.55) | 1 (0.25) |
| Mutant | Wild type | 104 (53.33) | 197 (45.08) | 188 (47.36) |
| Mutant | Mutant | 87 (44.62) | 191 (43.71) | 175 (44.08) |
| Wild type | Mutant | 1 (0.51) | 16 (3.66) | 33 (8.31) |
| Total | 195 (100) | 437 (100) | 397 (100) | |
a
A total of 5,536 genetic sequences were queried. The frequencies of mutations 44D, 44A, and 118I in the genetic database were 9.23, 1.46, and 15.07%, respectively.