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. 2022 Mar 11;78(Pt 4):494–508. doi: 10.1107/S2059798322001772

Figure 5.

Figure 5

AlphaFold2-derived predictions of MSMEG_0317 (AF MSMEG_0317) and Rv0227c (AF Rv0227c). (a) Structure of AF Rv0227c. (b) Structure of AF MSMEG_0317Δ. (c) Overlay of the crystal structure of MSMEG_0317Δ with AF Rv0227c and a close-up view of the base of the β-barrel core. Loop 6 in AF Rv0227c is resolved and this loop contains two additional β-strands. Loop 9 in AF Rv0227c adopts an ‘out’ or ‘open’ conformation, in contrast to loop 9 in the MSMEG_0317Δ crystal structure, which adopts an ‘in’ or ‘closed’ conformation. (d) Overlay of the crystal structure of MSMEG_0317Δ with AF MSMEG_0317 and a close-up view of the base of the β-barrel core. Loop 6 in AF MSMEG_0317 is resolved in a similar position as in AF Rv0227c, including the additional two β-strands. Like AF Rv0227c, loop 9 in AF MSMEG_0317 adopts an ‘out’ or ‘open’ conformation. (e) Comparison of the enclosed cavities of the MSMEG_0317Δ, AF Rv0227c and AF MSMEG_0317 models. See also Supplementary Fig. S7.