Table 3.
Summary of meta-analysis results.
| Group 1 | Group 2 | Direct comparisons | Network meta-analysis | ||||
|---|---|---|---|---|---|---|---|
| Difference (95% CI) a | P value | I 2 | Difference (95% CI)a | P value | |||
| ADSC studies | Sham | BCNI | –71 (–84, –58) | <0.001 | 99% | –73 (–86, –59) | <0.001 |
| Vehicle | –68 (–85, –52) | <0.001 | 99% | –69 (–85, –53) | <0.001 | ||
| Stem cell | –44 (–54, –34) | <0.001 | 99% | –44 (–57, –32) | <0.001 | ||
| Co-intervention | –42 (–55, –28) | <0.001 | 99% | –42 (–57, 28) | <0.001 | ||
| Combined | –21 (–33, –9) | 0.001 | 99% | –23 (–39, –7) | 0.006 | ||
| BCNI | Vehicle | 17 (–4, 38) | 0.12 | 99% | 3 (–15, 21) | 0.73 | |
| Stem cell | 27 (15, 39) | <0.001 | 99% | 28 (15, 42) | <0.001 | ||
| Co-intervention | 31 (20, 50) | <0.001 | 99% | 30 (15, 45) | <0.001 | ||
| Combined | 48 (32, 65) | <0.001 | 99% | 49 (33, 66) | <0.001 | ||
| Vehicle | Stem cell | 30 (13, 48) | 0.001 | 99% | 24 (7, 40) | 0.005 | |
| Co-intervention | 10 (–5, 24) | 0.21 | 97% | 25 (6, 44) | 0.008 | ||
| Combined | 15 (2, 27) | 0.03 | 97% | 44 (25, 65) | <0.001 | ||
| Stem cell | Co-intervention | 5 (–4, 13) | 0.28 | 98% | 2 (–13, 16) | 0.83 | |
| Combined | 22 (7, 36) | 0.003 | 99% | 21 (5, 37) | 0.01 | ||
| Co-intervention | Combined | 25 (11, 39) | <0.001 | 99% | 20 (3, 37) | 0.02 | |
| BMSC studies | Sham | BCNI | –42 (–45, –39) | <0.001 | (+) | –48 (–67, –31) | <0.001 |
| Vehicle | –72 (–92, –51) | <0.001 | 99% | –71 (–82, –60) | <0.001 | ||
| Stem cell | –27 (–39, –16) | <0.001 | 98% | –27 (–38, –16) | <0.001 | ||
| Co-intervention | –32 (–37, –27) | <0.001 | 83% | –36 (–48, –24) | <0.001 | ||
| Combined | –7 (–16, 1) | 0.10 | 96% | –16 (–32, 0) | 0.05 | ||
| BCNI | Vehicle | (#) | – | – | –22 (–41, –4) | 0.02 | |
| Stem cell | 23 (11, 36) | <0.001 | 98% | 21 (5, 38) | 0.01 | ||
| Co-intervention | 8 (6, 10) | <0.001 | (+) | 13 (–5, 31) | 0.17 | ||
| Combined | 30 (28, 32) | <0.001 | (+) | 32 (12, 53) | 0.002 | ||
| Vehicle | Stem cell | 43 (33, 52) | <0.001 | 96% | 44 (32, 55) | <0.001 | |
| Co-intervention | 30 (12, 48) | 0.001 | 98% | 35 (22, 48) | <0.001 | ||
| Combined | 37 (35, 39) | <0.001 | (+) | 54 (38, 71) | <0.001 | ||
| Stem cell | Co-intervention | –7 (–18, 4) | 0.23 | 98% | –9 (–21, 4) | 0.17 | |
| Combined | 10 (4, 16) | 0.001 | 94% | 10 (–5, 26) | 0.18 | ||
| Co-intervention | Combined | 22 (20, 24) | <0.001 | 0% | 19 (3, 36) | 0.02 | |
ADSC, adipose-derived stem cell; BCNI, bilateral cavernous nerve injury; BMSC, bone marrow–derived stem cell; CI, confidence interval.
a
Differences reported as Group 2 minus Group 1.