Table 3.

Results for the multivariate regression models for the weighted and Box–Cox-transformed values of transaminases.

Outcome	Variables	Estimate (β)	SE	edf	P
AST (UI/L)	Intercept	− 2.697	1.090	1.000	0.014
	Exitus (Ref: Alive)	0.060	0.108	1.000	0.579
	D-dimer	0.952	0.452	1.000	0.036
	IL-6	0.102	0.029	1.000	< 0.001
	s(Age)	See Fig. 2		1.000	0.715
	s(Time) (Alive)	See Fig. 2		4.892	< 0.001
	s(Time) (Deceased)	See Fig. 2		1.001	0.270
ALT (UI/L)	Intercept	− 1.657	0.713	1.000	0.020
	Exitus (Ref: Alive)	− 0.251	0.126	1.000	0.046
	CRP	− 0.008	0.001	1.000	< 0.001
	D-dimer	0.579	0.265	1.000	0.029
	s(Age)	See Fig. 2		2.988	0.003
	s(Time) (Alive)	See Fig. 2		4.689	< 0.001
	s(Time) (Deceased)	See Fig. 2		3.965	< 0.001
GGT (UI/L)	Intercept	− 4.028	1.135	1.000	< 0.001
	Sex (Ref: Male)	0.339	0.126	1.000	0.008
	Exitus(Ref: Alive)	− 0.131	0.190	1.000	0.490
	CRP	− 0.002	0.002	1.000	0.373
	D-dimer	1.549	0.465	1.000	< 0.001
	IL-6	− 0.017	0.030	1.000	0.566
	Lymphocytes	− 0.007	0.003	1.000	0.021
	s(Age)	See Fig. 2		2.777	0.085
	s(Time) (Alive)	See Fig. 2		5.103	< 0.001
	s(Time) (Deceased)	See Fig. 2		4.194	< 0.001
ALP (UI/L)	Intercept	− 0.584	0.055	1.000	< 0.001
	Exitus (Ref: Alive)	0.242	0.131	1.000	0.065
	s(Age)	See Fig. 2		2.054	0.569
	s(Time) (Alive)	See Fig. 2		4.397	0.004
	s(Time) (Deceased)	See Fig. 2		3.871	< 0.001

SE means standard error. The edf number represents the parameters needed to estimate the effect of a covariate, indicating the complexity of the functional form of the smooth effect.