Table 2.
Univariate and multivariate logistic-regression analysis on risk factors for recurrence of conventional adenomas and serrated polyps
| Characteristic | Conventional adenomas |
Serrated polyps |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of patients (n = 668) | Recurrence (n = 284) | Univariate |
Multivariate |
No. of patients (n = 385) | Recurrence (n = 177) | Univariate |
Multivariate |
|||||
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | |||||
| Age | ||||||||||||
| <50 years | 233 | 79 (33.9) | 1 | 1 | 179 | 67 (37.4) | 1 | 1 | ||||
| ≥50 years | 435 | 205 (47.1) | 1.74 (1.25–2.42) | <0.01 | 1.64 (1.15–2.35) | <0.01 | 206 | 110 (53.4) | 2.49 (1.62–3.84) | <0.01 | 2.06 (1.31–3.23) | <0.01 |
| Gender | ||||||||||||
| Female | 247 | 86 (34.8) | 1 | 1 | 143 | 46 (32.2) | 1 | 1 | ||||
| Male | 421 | 198 (47.0) | 1.66 (1.20–2.30) | <0.01 | 1.33 (0.92–1.93) | 0.13 | 242 | 131 (54.1) | 1.92 (1.27–2.88) | <0.01 | 1.72 (1.02–2.89) | 0.04 |
| Body mass index | ||||||||||||
| <24 kg/m2 | 380 | 147 (38.7) | 1 | 1 | 236 | 88 (37.3) | 1 | 1 | ||||
| ≥24 kg/m2 | 288 | 137 (47.6) | 1.44 (1.05–1.96) | 0.02 | 1.36 (1.03–1.89) | 0.03 | 149 | 89 (59.7) | 2.55 (1.64–3.80) | <0.01 | 2.25 (1.43–3.55) | <0.01 |
| Anatomical location | ||||||||||||
| Proximal colon | 218 | 102 (46.8) | 1 | 101 | 43 (42.6) | 1 | ||||||
| Distal colon | 320 | 130 (40.6) | 0.78 (0.55–1.10) | 0.16 | 130 | 68 (52.3) | 1.48 (0.88–2.50) | 0.14 | ||||
| Rectum | 130 | 52 (40.0) | 0.76 (0.49–1.18) | 0.22 | 154 | 66 (42.9) | 1.01 (0.61–1.68) | 0.96 | ||||
| Number of polyps | ||||||||||||
| <3 | 604 | 244 (40.4) | 1 | 1 | 336 | 145 (43.2) | 1 | 1 | ||||
| ≥3 | 64 | 40 (62.5) | 2.46 (1.45–4.18) | <0.01 | 1.98 (1.14–3.45) | 0.02 | 49 | 32 (65.3) | 2.48 (1.33–4.64) | <0.01 | 1.87 (1.11–3.69) | 0.02 |
| Size (mm) | ||||||||||||
| <10 | 469 | 202 (43.1) | 1 | 358 | 165 (46.1) | 1 | ||||||
| ≥10 | 199 | 82 (41.2) | 0.93 (0.66–1.30) | 0.66 | 27 | 12 (44.4) | 0.84 (0.43–2.06) | 0.87 | ||||
| High-grade dysplasia | ||||||||||||
| No | 571 | 244 (42.7) | 1 | 379 | 172 (45.4) | 1 | ||||||
| Yes | 97 | 40 (41.2) | 0.94 (0.61–1.46) | 0.78 | 6 | 5 (83.3) | 6.02 (0.70–52.00) | 0.10 | ||||
| Smoker status | ||||||||||||
| Never | 538 | 212 (39.4) | 1 | 1 | 291 | 118 (40.6) | 1 | 1 | ||||
| Current | 130 | 72 (55.4) | 1.91 (1.30–2.81) | <0.01 | 1.38 (1.19–2.15) | 0.02 | 94 | 59 (62.8) | 2.47 (1.53–4.00) | <0.01 | 1.38 (0.76–2.49) | 0.29 |
| Alcohol consumption | ||||||||||||
| Never | 625 | 256 (41.0) | 1 | 1 | 357 | 157 (44.0) | 1 | 1 | ||||
| Current | 43 | 28 (61.1) | 2.69 (1.41–5.14) | <0.01 | 1.84 (1.01–3.67) | 0.04 | 28 | 20 (71.4) | 3.19 (1.37–7.42) | <0.01 | 1.73 (0.67–4.46) | 0.26 |
| History of hypertension | ||||||||||||
| No | 534 | 216 (40.4) | 1 | 1 | 308 | 135 (43.8) | 1 | |||||
| Yes | 134 | 68 (50.7) | 1.52 (1.04–2.22) | 0.03 | 1.29 (0.85–1.94) | 0.23 | 77 | 42 (54.5) | 1.54 (0.93–2.54) | 0.09 | ||
| History of diabetes | ||||||||||||
| No | 638 | 270 (42.3) | 1 | 364 | 161 (44.2) | 1 | 1 | |||||
| Yes | 30 | 14 (46.7) | 1.19 (0.57–2.49) | 0.64 | 21 | 16 (76.2) | 4.04 (1.45–11.25) | <0.01 | 2.17 (0.73–6.50) | 0.17 | ||
| Family history of polyps | ||||||||||||
| No | 622 | 258 (41.5) | 1 | 1 | 344 | 155 (45.1) | 1 | |||||
| Yes | 46 | 26 (56.5) | 1.83 (1.00–3.36) | 0.04 | 2.81 (1.42–5.57) | <0.01 | 41 | 22 (53.7) | 1.41 (0.74–2.70) | 0.30 | ||
| Family history of CRC | ||||||||||||
| No | 626 | 256 (40.9) | 1 | 1 | 362 | 165 (45.6) | 1 | |||||
| Yes | 42 | 28 (66.7) | 2.89 (1.49–5.60) | <0.01 | 1.95 (1.04–3.67) | 0.04 | 23 | 12 (52.2) | 1.30 (0.56–3.03) | 0.54 | ||
OR, odds ratio; CI, confidence interval; BMI, body mass index; CRC, colorectal cancer.