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ADC measurements of prostate cancer (PCa) on an ADC map using three different ROI protocols. (a) Freehand ROI: ROI was drawn along the border of the low signal comprising the tumor to cover the entire tumor area. (b) Large-circle ROI: ROI was defined to be as large as possible for the target lesion. (c) Small-circles ROI: Small ROIs were positioned within the same slice but not overlapping each other.
