Table 2. In Silico Molecular Docking Based Binding Energy Estimation of Synthesized Bis(indolyl)methane Derivatives with the Motor Domain of Mitotic Kinesin Eg5 and Its Recently Reported Drug-Resistant Point Mutant Variants.

	binding energy (ΔG)
		drug-resistant Eg5 mutants
bis(indolyl)methane derivatives	WT Eg5 kinesin (kcal/mol)	D130A (kcal/mol)	L214A (kcal/mol)
3k	–11.2	–11.1	–10.5
3b	–11.2	–11.0	–9.7