TABLE 4.

Dose proportionality power model results (with and without data for 0.35-mg/kg dose group)

Parameter	Day	Adjusted mean slope	90% CIa
			Lower	Upper
Including data for 0.35-mg/kg dose group
AUC∞ (ng · h/ml)	1	0.902	0.822	0.982
AUC24 (ng · h/ml)b	28	0.894	0.807	0.981
Cmax (ng/ml)	1	0.839	0.718	0.960
	28	0.916	0.791	1.041
Removing data for 0.35-mg/kg dose group
AUC∞ (ng · h/mL)	1	0.907	0.737	1.077
AUC24 (ng · h/mL)b	28	0.967	0.801	1.132
Cmax (ng/ml)	1	0.696	0.432	0.960
	28	1.115	0.873	1.358

^aCI, confidence interval. 

^bFor the 0.35-mg/kg b.d., 1.5-mg/kg b.d., and 4-mgkg b.d. treatment groups, AUC₂₄ was calculated as AUC_last multiplied by 2.