Table 3.
Baseline characteristics of the included patients. The first number is the number of patients with the event or the sample mean value ± standard deviation of the variable, and the second is the number of patients for whom the event was described. Statistically significant differences were marked with an asterisk (*).
| Baseline variable | BAV (n=917) | TAV (n=3079) | OR/WMD [95% CI] | P-value |
|---|---|---|---|---|
| Age (years±SD) | 76.8±7.43 | 78.5±7.12 | WMD -0.89 [-1.60, -0.17] | 0.02* |
| Male (%) | 562/917 (61.3) | 1554/3079 (50.5) | OR 1.10 [0.93, 1.31] | 0.27 |
| Diabetes mellitus (%) | 226/917 (24.6) | 980/3079 (31.8) | OR 1.00 [0.82, 1.21] | 0.98 |
| Previous stroke (%) | 130/917 (14.2) | 357/3079 (11.6) | OR 1.20 [0.94, 1.54] | 0.15 |
| Peripheral arterial disease (%) | 177/834 (21.2) | 690/2913 (23.7) | OR 0.95 [0.67, 1.34] | 0.76 |
| Hypertension (%) | 603/879 (68.6) | 1293/1722 (75.1) | OR 0.95 [0.78, 1.16] | 0.61 |
| COPD (%) | 194/834 (23.3) | 660/2913 (22.7) | OR 1.05 [0.84, 1.32] | 0.67 |
| Ischaemic heart disease (%) | 175/339 (51.6) | 1472/2437 (60.4) | OR 0.99 [0.76, 1.29] | 0.92 |
| Previous CABG (%) | 75/710 (10.6) | 340/2178 (15.6) | OR 0.85 [0.62, 1.17] | 0.33 |
| Previous PCI (%) | 180/797 (22.6) | 709/2248 (31.5) | OR 0.89 [0.71, 1.11] | 0.31 |
| NYHA class III-IV (%) | 632/797 (79.3) | 1874/2248 (83.4) | OR 1.09 [0.86, 1.37] | 0.48 |
| Atrial fibrillation (%) | 49/273 (17.9) | 189/996 (19.0) | OR 0.94 [0.64, 1.38] | 0.74 |
| EuroSCORE (%±SD) | 17.4±10.5 | 19.4±12.6 | WMD -1.15 [-2.63, 0.33] | 0.13 |
| STS score (%±SD) | 6.10±3.88 | 6.53±3.98 | WMD 0.06 [-0.28, 0.40] | 0.73 |
| Aortic valve area (cm2±SD) | 0.629±0.173 | 0.660±0.239 | WMD -0.03 [-0.06, 0.01] | 0.11 |
| Trans-aortic valve gradient (mmHg±SD) | 52.6±17.3 | 49.8±16.1 | WMD 1.73 [0.31, 3.16] | 0.02* |
| Aortic annular diameter (mm±SD) | 23.6±4.42 | 24.3±3.72 | WMD -0.23 [-1.63, 1.17] | 0.74 |
| Left ventricular ejection fraction (%±SD) | 51.3±14.2 | 53.6±13.0 | WMD -2.60 [-5.57, 0.37] | 0.09 |
| Ascending aortic diameter (mm±SD) | 38.4±5.00 | 34.2±3.63 | WMD 3.92 [3.02, 4.83] | <0.0001* |
BAV=bicuspid aortic valve; CABG=coronary artery bypass graft; CI=confidence interval; COPD=chronic obstructive pulmonary disease; NYHA=New York Heart Association; PCI=percutaneous coronary intervention; STS=Society of Thoracic Surgeons;
WMD=weighted mean difference