TABLE 3.
AUC0–24/MIC, peak/MIC, and T > MIC of each fluoroquinolone against each isolatea
| Antimicrobial agent | AUC0–24/MIC
|
Peak/MIC
|
T > MIC (%)
|
|||
|---|---|---|---|---|---|---|
| 68 | 79 | 68 | 79 | 68 | 79 | |
| Trovafloxacin | 405.9 (5.9) | 292.6 (1.4) | 27.2 (0.41) | 20.7 (2.0) | 100 | 100 |
| Gatifloxacin | 167.1 (4.5) | 189.8 (12.6) | 15.4 (22.6) | 183. (10.8) | 100 | 100 |
| Clinafloxacin | 215.1 (32.0) | 526.9 (4.9) | 18.8 (33.6) | 37.9 (3.3) | 100 | 100 |
| Sparfloxacin | 137 (11.2) | 46.7 (6.2) | 9.6 (12.8) | 3.8 (0.74) | 100 | 100 |
| Levofloxacin | 135 (9.2) | 58.2 (2.4) | 15.4 (19.7) | 6.6 (1.3) | 86 (5.8) | 76 (9.3) |
| Ciprofloxacin | 121.8 (12.6) | 40.8 (27.5) | 14.5 (5.9) | 5.6 (3.6) | 100 | 55 (15.7) |
a
Results are means, with the percent coefficient of variation given in parentheses.