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. 2022 Mar 18;10:855755. doi: 10.3389/fbioe.2022.855755

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Copyright © 2022 Kim, Ahn, Deans, Thompson, Ferland, Divakar, Dominas and Jonas.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Principal component analysis reveals distinct phenotype of drug activity at t = 7 days (B) Identification of most significantly affected individual markers from principal component from all drugs tested in TG model (C) Drug effects in reduction of AD-associated markers (z-score). Highlighted are key markers of tauopathy (Tau: red; phospho-Tau T231: magenta; phospho-Tau T404: blue; and Neprilysin: green).