Figure 5.

Impact of four-week rapamycin treatment on PC survival. Treatment with rapamycin for four weeks is sufficient to prevent reduced PC function. A, Midline vermis sagittal sections are stained with anti-calbindin antibody. Studies show PC loss is prevented by four-week treatment paradigm. B, PC numbers quantified. Two-way ANOVA, Bonferroni's post hoc testing. *p < 0.05, **p < 0.01, ***p < 0.001 ****, and p < 0.0001. ns, not significant; VEH, vehicle; RAPA, rapamycin. Scale bar: 100 µm. Data are reported as mean ± SEM.