Inhibitory effects of synthetic oxime derivatives on different types of cancer cells.
Comp. | Antiproliferative activity IC50 ± SD (μM) | ||||
---|---|---|---|---|---|
A375 | MCF-7 | A-549 | HT-29 | H-460 | |
10a | 6.93 ± 1.87 | 4.61 ± 1.14 | 3.59 ± 0.51 | 4.47 ± 0.49 | 6.31 ± 0.09 |
10b | 6.55 ± 0.93 | 3.69 ± 1.00 | 2.83 ± 0.74 | 14.13 ± 0.03 | 4.99 ± 1.25 |
10c | 9.01 ± 1.56 | 6.14 ± 0.28 | 4.58 ± 1.06 | 18.12 ± 0.99 | 6.74 ± 1.08 |
10d | 4.15 ± 1.48 | 3.22 ± 0.49 | 2.74 ± 0.53 | 7.29 ± 1.31 | 3.81 ± 0.78 |
10e | 2.62 ± 1.82 | 2.40 ± 0.50 | 1.80 ± 0.61 | 8.80 ± 0.73 | 2.52 ± 0.71 |
10f | 2.43 ± 1.51 | 0.85 ± 0.38 | 1.42 ± 0.42 | 7.83 ± 1.23 | 1.83 ± 0.68 |
10g | 7.57 ± 1.39 | 5.29 ± 0.42 | 3.61 ± 0.67 | 17.34 ± 0.89 | 6.68 ± 0.59 |
11a | 4.97 ± 0.72 | 3.11 ± 0.30 | 2.71 ± 0.90 | 9.10 ± 0.21 | 3.87 ± 1.01 |
11b | 8.63 ± 1.00 | 5.94 ± 0.86 | 4.39 ± 0.26 | 18.09 ± 0.29 | 6.71 ± 0.36 |
11c | 9.74 ± 1.34 | 8.09 ± 0.36 | 4.80 ± 1.18 | 19.08 ± 0.58 | 7.37 ± 0.72 |
11d | 1.47 ± 1.36 | 0.79 ± 0.72 | 1.32 ± 0.50 | 3.80 ± 0.11 | 1.63 ± 0.43 |
11e | 2.69 ± 0.98 | 2.72 ± 0.80 | 1.18 ± 0.86 | 7.35 ± 0.59 | 2.76 ± 0.87 |
11f | 2.42 ± 1.38 | 2.76 ± 0.15 | 1.48 ± 0.48 | 6.03 ± 1.17 | 2.17 ± 1.21 |
11g | 0.87 ± 1.60 | 0.28 ± 0.70 | 1.25 ± 0.62 | 2.43 ± 1.24 | 1.04 ± 0.05 |
Cisplatin | 9.46 ± 0.14 | 12.25 ± 0.95 | 5.12 ± 0.23 | 25.4 ± 0.23 | 6.84 ± 0.92 |
Foretinib | 1.9 ± 0.02 | 1.18 ± 0.06 | 1.15 ± 0.05 | 3.97 ± 0.05 | 2.86 ± 0.04 |