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. 2022 Apr 1;12(17):10307–10320. doi: 10.1039/d2ra01198k

Inhibitory effects of synthetic oxime derivatives on different types of cancer cells.

Comp. Antiproliferative activity IC50 ± SD (μM)
A375 MCF-7 A-549 HT-29 H-460
10a 6.93 ± 1.87 4.61 ± 1.14 3.59 ± 0.51 4.47 ± 0.49 6.31 ± 0.09
10b 6.55 ± 0.93 3.69 ± 1.00 2.83 ± 0.74 14.13 ± 0.03 4.99 ± 1.25
10c 9.01 ± 1.56 6.14 ± 0.28 4.58 ± 1.06 18.12 ± 0.99 6.74 ± 1.08
10d 4.15 ± 1.48 3.22 ± 0.49 2.74 ± 0.53 7.29 ± 1.31 3.81 ± 0.78
10e 2.62 ± 1.82 2.40 ± 0.50 1.80 ± 0.61 8.80 ± 0.73 2.52 ± 0.71
10f 2.43 ± 1.51 0.85 ± 0.38 1.42 ± 0.42 7.83 ± 1.23 1.83 ± 0.68
10g 7.57 ± 1.39 5.29 ± 0.42 3.61 ± 0.67 17.34 ± 0.89 6.68 ± 0.59
11a 4.97 ± 0.72 3.11 ± 0.30 2.71 ± 0.90 9.10 ± 0.21 3.87 ± 1.01
11b 8.63 ± 1.00 5.94 ± 0.86 4.39 ± 0.26 18.09 ± 0.29 6.71 ± 0.36
11c 9.74 ± 1.34 8.09 ± 0.36 4.80 ± 1.18 19.08 ± 0.58 7.37 ± 0.72
11d 1.47 ± 1.36 0.79 ± 0.72 1.32 ± 0.50 3.80 ± 0.11 1.63 ± 0.43
11e 2.69 ± 0.98 2.72 ± 0.80 1.18 ± 0.86 7.35 ± 0.59 2.76 ± 0.87
11f 2.42 ± 1.38 2.76 ± 0.15 1.48 ± 0.48 6.03 ± 1.17 2.17 ± 1.21
11g 0.87 ± 1.60 0.28 ± 0.70 1.25 ± 0.62 2.43 ± 1.24 1.04 ± 0.05
Cisplatin 9.46 ± 0.14 12.25 ± 0.95 5.12 ± 0.23 25.4 ± 0.23 6.84 ± 0.92
Foretinib 1.9 ± 0.02 1.18 ± 0.06 1.15 ± 0.05 3.97 ± 0.05 2.86 ± 0.04