Effects of selected synthetic compounds on tubulin polymerization, EGFR, BRAFV600E and c-Met.
| Comp. | EGFR inhibition, IC50 ± SD (μM) | BRAF inhibition, IC50 ± SD (μM) | c-Met inhibition, IC50 ± SD (μM) | Tubulin polymerization, IC50 ± SD (μM) |
|---|---|---|---|---|
| 8a | 7.54 ± 0.05 | 3.97 ± 0.04 | 3.78 ± 0.29 | 3.71 ± 0.82 |
| 8d | 19.65 ± 1.07 | 15.04 ± 1.02 | 3.61 ± 0.94 | 1.10 ± 0.07 |
| 9a | 2.28 ± 0.42 | 3.11 ± 0.09 | 2.36 ± 0.09 | 4.42 ± 1.22 |
| 9e | 2.61 ± 2.94 | 10.30 ± 1.07 | 6.60 ± 0.76 | 5.61 ± 0.91 |
| 10d | 22.5 ± 1.52 | 7.39 ± 0.98 | 1.47 ± 0.09 | 0.41 ± 0.02 |
| 10e | 12.9 ± 0.58 | 9.31 ± 1.82 | 5.64 ± 0.95 | 1.51 ± 0.24 |
| 10f | 14.2 ± 0.74 | 14.94 ± 1.20 | 3.86 ± 0.43 | 2.21 ± 0.52 |
| 11d | 0.027 ± 0.004 | 5.20 ± 0.87 | 3.71 ± 0.95 | 1.12 ± 0.04 |
| 11e | 1.098 ± 0.021 | 16.45 ± 1.29 | 4.10 ± 0.42 | 1.72 ± 0.92 |
| 11g | 1.09 ± 0.028 | 15.48 ± 1.76 | 3.51 ± 0.55 | 1.51 ± 0.42 |
| Foretinib | 0.075 ± 0.005 | 0.09 ± 0.02 | 0.024 ± 0.002 | — |
| Colchicine | — | — | — | 0.55 ± 0.02 |
| Vinorelbine | — | — | — | 31.7 ± 1.5 |