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. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: Pharmacol Biochem Behav. 2022 Jan 22;213:173339. doi: 10.1016/j.pbb.2022.173339

Figure 6:

Figure 6:

Region-specific decreases CB1 receptor binding in the brains of aged versus young adult rats. Coronal brain sections were incubated with the CB1 receptor agonist [3H]CP55,940 (4 nM). Non-specific binding was defined in the presence of AM251 (1 mM). Specific binding of [3H]CP55,940 is expressed as fmol/mg protein. (A) CB1 receptor binding was reduced in medial prefrontal cortex (mPFCx), temporal cortex (TmpCx) and entorhinal cortex (EntCx), but not in anterior cingulate cortex (aCgCx). (B) CB1 receptor binding in CA1, CA2/3, dentate gyrus (DG) regions of dorsal hippocampus, caudate (CPu) and nucleus accumbens (NAc) was statistically similar in young adult and aged rats. Data are presented as mean±SEM, n = 8 per group. * p < 0.05, per a Student’s t-test corrected for multiple comparisons using the Bonferroni method.