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. 2022 Feb 7;21(8):780–791. doi: 10.1080/15384101.2022.2031426

Figure 4.

Figure 4.

UBE2T depletion inhibited EMT process by inducing autophagy via suppressing AKT/mTOR in OC cells. A Western blot indicating the level of N-cad, E-cad, Slug, and MMP2 in OC cells with UBE2T silencing. B Western blot indicating the level of p-AKT (S473), AKT, p-mTOR (S2448) and mTOR in OC cells with UBE2T depletion. C Western blot showing the level of BECN1, p62, and LC3A/B-I/II in OC cells with UBE2T knockdown. D Western blot indicating the accumulated LC3A/B-II of OC cells with UBE2T knockdown under CQ (50 μM) treatment. E Western blot indicating the influences of MK2206 (2.5 μM) on the rescue effects of UBE2T on AKT and autophagy activity, reflected by the level of p-AKT(S473), AKT, and LC3A/B, in OC cells with UBE2T knockdown. F Western blot indicating the influences of BECN1 knockdown on BECN1 and LC3A/B-I/II, and the level of EMT related proteins, N-cad, E-cad, and Slug, with UBE2T knockdown.