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. 2022 Mar 18;9:870680. doi: 10.3389/fnut.2022.870680

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Copyright © 2022 Liu, Gu, Qu, Bao, Li and Cai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cholesterol metabolism was modulated by Porcine epidemic diarrhea virus (PEDV) infection indicated by transcriptional profiling of piglet livers. (A) PEDV RNA expression was determined by Quantitative Real-Time PCR (qRT-PCR) analysis in the jejunum and liver tissues of PEDV-infected and control piglets. (B) Volcano plot visualization of the hepatic transcriptome measured by RNA-seq analysis. (C) Genes involved in the cholesterol biosynthesis pathway were among the most enriched pathways based on gene ontology (GO) analysis. (D) The gene-set enrichment analysis (GSEA) plot of the differentially expressed genes in the cholesterol biosynthesis pathway of livers from PEDV-infected piglets compared to the controls. False-discovery rate (FDR).