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. 2022 Mar 18;9:870680. doi: 10.3389/fnut.2022.870680

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Copyright © 2022 Liu, Gu, Qu, Bao, Li and Cai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PEDV infection epigenetically inhibited the transcriptional activation of gene expression by SREBP2 and FXR. (A) The interactions among SREBP2, FXR, and core proteins involved in cholesterol metabolism during transcriptional regulation were predicted by Search Tool for the Retrieval of Interacting Genes (STRING). (B,C) The relative enrichment of SREBP2 and FXR at the locus of indicated genes in livers was analyzed by ChIP-qPCR. (D,E) The relative enrichment of histone H3K27ac and H3K4me1 occupancy was analyzed by ChIP-qPCR. The data are shown as the means ± SEM, *P < 0.05, ** P < 0.01 using the two-tailed Student t-test.