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. 2000 Mar;44(3):614–618. doi: 10.1128/aac.44.3.614-618.2000

TABLE 3.

Influence of immunosuppression and starting time of treatment on efficacy of FK463 in mouse models of disseminated candidiasis

Host condition Starting time of treatment after infection (h) Inoculum (CFU) ED50 (mg/kg/day)a of:
FK463 FLCZ AMPH-B
Normal (untreated) 1b 1.9 × 106 0.13 (0.09–0.18) 1.5 (1.10–2.15) 0.04 (0.03–0.06)
Hydrocortisone treated 1b 1.3 × 105 0.45 (0.32–0.64) 14.9 (9.91–38.3) 0.23 (0.16–0.32)
Cyclophosphamide treated 1b 3.1 × 104 0.28 (NE) ≥4.0d (NE) 0.13 (NE)
1b 1.2 × 104 0.25 (NE)  2.0 (1.40–2.85) 0.07 (0.05–0.10)
24c 1.2 × 104 0.32 (0.24–0.45)  6.2 (4.49–8.43) 0.21 (0.15–0.29)
a

Values in parentheses are 95% confidence intervals. NE, confidence interval could not be estimated. 

b

Once daily for 4 days, starting at 1 h after infection. 

c

Once daily for 3 days, starting at 24 h after infection. 

d

Fifty-percent survival was observed at 4.0 mg/kg of FLCZ.